Comment

. 2021 Oct;47(10):1173-1174.

doi: 10.1007/s00134-021-06482-3. Epub 2021 Jul 27.

Ketamine-induced cholangiopathy in ARDS patients

Christian de Tymowski^{1

2

3

4}, François Dépret^{5

6

7

8}, Emmanuel Dudoignon^{1

2

9}, Matthieu Legrand^{9

10

11}, Vincent Mallet^{1

2

12}; Keta-Cov Research Group

Collaborators, Affiliations

Affiliations

¹ Department of Anesthesiology and Critical Care and Burn Unit, Assistance Publique-Hôpitaux de Paris (AP-HP), Groupe Hospitalier St-Louis-Lariboisière, Paris, France.
² University de Paris, Paris, France.
³ Centre de Recherche sur l'Inflammation (CRI), INSERM U1149, Paris, France.
⁴ Laboratoire d'Excellence (Labex) Inflammex, ComUE Sorbonne Paris Cité, Paris, France.
⁵ Department of Anesthesiology and Critical Care and Burn Unit, Assistance Publique-Hôpitaux de Paris (AP-HP), Groupe Hospitalier St-Louis-Lariboisière, Paris, France. francois.depret@aphp.fr.
⁶ University de Paris, Paris, France. francois.depret@aphp.fr.
⁷ Institut National de La Santé Et de La Recherche Médicale (INSERM), UMR INSERM 942, Lariboisière Hospital University Paris Diderot, 75475, Paris, France. francois.depret@aphp.fr.
⁸ F-CRIN INI-CRCT Network, Nancy, France. francois.depret@aphp.fr.
⁹ Institut National de La Santé Et de La Recherche Médicale (INSERM), UMR INSERM 942, Lariboisière Hospital University Paris Diderot, 75475, Paris, France.
¹⁰ F-CRIN INI-CRCT Network, Nancy, France.
¹¹ Department of Critical Care and Peri Operative Medicine, University of California, San Francisco, USA.
¹² AP-HP Centre, Groupe Hospitalier Cochin Port Royal, DMU Cancérologie Et Spécialités Médico-Chirurgicales, Service d'Hépatologie, Université de Paris, Paris, France.

PMID: 34313797
PMCID: PMC8315088
DOI: 10.1007/s00134-021-06482-3

Comment

Ketamine-induced cholangiopathy in ARDS patients

Christian de Tymowski et al. Intensive Care Med. 2021 Oct.

. 2021 Oct;47(10):1173-1174.

doi: 10.1007/s00134-021-06482-3. Epub 2021 Jul 27.

Authors

Christian de Tymowski^{1

2

3

4}, François Dépret^{5

6

7

8}, Emmanuel Dudoignon^{1

2

9}, Matthieu Legrand^{9

10

11}, Vincent Mallet^{1

2

12}; Keta-Cov Research Group

Affiliations

¹ Department of Anesthesiology and Critical Care and Burn Unit, Assistance Publique-Hôpitaux de Paris (AP-HP), Groupe Hospitalier St-Louis-Lariboisière, Paris, France.
² University de Paris, Paris, France.
³ Centre de Recherche sur l'Inflammation (CRI), INSERM U1149, Paris, France.
⁴ Laboratoire d'Excellence (Labex) Inflammex, ComUE Sorbonne Paris Cité, Paris, France.
⁵ Department of Anesthesiology and Critical Care and Burn Unit, Assistance Publique-Hôpitaux de Paris (AP-HP), Groupe Hospitalier St-Louis-Lariboisière, Paris, France. francois.depret@aphp.fr.
⁶ University de Paris, Paris, France. francois.depret@aphp.fr.
⁷ Institut National de La Santé Et de La Recherche Médicale (INSERM), UMR INSERM 942, Lariboisière Hospital University Paris Diderot, 75475, Paris, France. francois.depret@aphp.fr.
⁸ F-CRIN INI-CRCT Network, Nancy, France. francois.depret@aphp.fr.
⁹ Institut National de La Santé Et de La Recherche Médicale (INSERM), UMR INSERM 942, Lariboisière Hospital University Paris Diderot, 75475, Paris, France.
¹⁰ F-CRIN INI-CRCT Network, Nancy, France.
¹¹ Department of Critical Care and Peri Operative Medicine, University of California, San Francisco, USA.
¹² AP-HP Centre, Groupe Hospitalier Cochin Port Royal, DMU Cancérologie Et Spécialités Médico-Chirurgicales, Service d'Hépatologie, Université de Paris, Paris, France.

PMID: 34313797
PMCID: PMC8315088
DOI: 10.1007/s00134-021-06482-3

No abstract available

PubMed Disclaimer

Conflict of interest statement

None.

Figures

**Fig. 1**
Proportion of patients with ALP < 4 N and ≥ 4 N between liberal and restrictive ketamine prescription period. KR ketamine restriction, *ALP* alkaline phosphatase, P p value

See this image and copyright information in PMC

Comment in

Role of intravenous ketamine in the pathogenesis of secondary sclerosing cholangitis in critically ill patients: perpetrator or innocent bystander? Answers provided by forensic toxicology.
Leonhardt S, Baumann S, Jürgensen C, Hüter L, Leonhardt J; Ketamine Cast Research Group. Leonhardt S, et al. Intensive Care Med. 2023 Dec;49(12):1549-1551. doi: 10.1007/s00134-023-07257-8. Epub 2023 Nov 9. Intensive Care Med. 2023. PMID: 37943301 Free PMC article. No abstract available.

Comment on

Secondary sclerosing cholangitis: an emerging complication in critically ill COVID-19 patients.
Meersseman P, Blondeel J, De Vlieger G, van der Merwe S, Monbaliu D; Collaborators Leuven Liver Transplant program. Meersseman P, et al. Intensive Care Med. 2021 Sep;47(9):1037-1040. doi: 10.1007/s00134-021-06445-8. Epub 2021 Jun 29. Intensive Care Med. 2021. PMID: 34185115 Free PMC article. No abstract available.

References

1. Meersseman P, Blondeel J, De Vlieger G, et al. Secondary sclerosing cholangitis: an emerging complication in critically ill COVID-19 patients. Intensive Care Med. 2021 doi: 10.1007/s00134-021-06445-8. - DOI - PMC - PubMed
1. Mallet V, Bock K, Mandengue PD, et al. Intravenous ketamine and progressive cholangiopathy in COVID-19 patients. J Hepatol. 2021;74:1243–1244. doi: 10.1016/j.jhep.2021.02.007. - DOI - PMC - PubMed
1. Chanques G, Constantin J-M, Devlin JW, et al. Analgesia and sedation in patients with ARDS. Intensive Care Med. 2020;46:2342–2356. doi: 10.1007/s00134-020-06307-9. - DOI - PMC - PubMed
1. Bütikofer S, Lenggenhager D, Garcia PDW, et al. Secondary sclerosing cholangitis as cause of persistent jaundice in patients with severe COVID-19. Liver Int. 2021 doi: 10.1111/liv.14971. - DOI - PMC - PubMed
1. ANSM . Kétamine: risque d’atteintes hépatiques graves lors d’utilisations prolongées et/ou à doses élevées—lettre aux professionnels de santé. France: ANSM; 2017.

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions

Substances

Actions

LinkOut - more resources

Full Text Sources

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Ketamine-induced cholangiopathy in ARDS patients

Collaborators

Affiliations

Ketamine-induced cholangiopathy in ARDS patients

Authors

Collaborators

Affiliations

Conflict of interest statement

Figures

Comment in

Comment on

References

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources