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Comment
. 2021 Aug 3;118(31):e2109994118.
doi: 10.1073/pnas.2109994118.

From single flies to many genes: Using Drosophila to explore the genetics of psychostimulant consumption

Iris Titos  1 , Adrian Rothenfluh  1   2
Affiliations
Comment

From single flies to many genes: Using Drosophila to explore the genetics of psychostimulant consumption

Iris Titos et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no competing interest.

Figures

Fig. 1.
Fig. 1.
Strategy used to identify SNPs involved in Drosophila cocaine and methamphetamine consumption. An advanced intercross population (AIP) containing 18,000 flies was subjected to single-fly feeding behavior of food containing only sucrose or sucrose supplemented with either cocaine or methamphetamine. From all the flies, the top 10% high consumers were selected and sequenced. The comparison of the top consumers sequence with that of a control population through extreme quantitative trait locus analysis (xQTL) allowed the identification of 3,033 single nucleotide polymorphisms (SNPs) that mapped to 1,962 genes that are involved in increased consumption in flies. Some of the genes and SNPs found in the screen were functionally assessed by RNA interference (RNAi) and allele-specific AIP libraries. Created with https://biorender.com/.
See this image and copyright information in PMC

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