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Comment
. 2021 Jul;9(7):e003044.
doi: 10.1136/jitc-2021-003044.

Letter to the editor: radiomics analysis for predicting pembrolizumab response in patients with advanced rare cancers

Mateus Trinconi Cunha  1 , Vinicius Jardim Carvalho  2 , Rafael Maffei Loureiro  3 , Carlos Eduardo Brantis-de-Carvalho  4 , Murilo Bicudo Cintra  5   6 , Gilberto de Castro Junior  7
Affiliations
Comment

Letter to the editor: radiomics analysis for predicting pembrolizumab response in patients with advanced rare cancers

Mateus Trinconi Cunha et al. J Immunother Cancer. 2021 Jul.

Abstract

A commentary on the original research article: 'Radiomics analysis for predicting pembrolizumab response in patients with advanced rare cancers'. Of note, the predictor selection process, the cross-validation method, along with the lack of final testing of the developed model with a separated data set may mask overfitting, overestimating performance metrics.

Keywords: immunotherapy.

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Conflict of interest statement

Competing interests: GdC has received personal fees from AstraZeneca, Bayer, Bristol-Myers Squibb, Boehringer Ingelheim, Janssen, Lilly, Merck Serono, Merck Sharp and Dohme, Novartis, Pfizer, Roche, Teva, and Yuhan, none related to this publication.

Comment in

  • Author response to Cunha et al.
    Colen RR, Rolfo C, Ak M, Ayoub M, Ahmed S, Elshafeey N, Mamindla P, Zinn PO, Ng C, Vikram R, Bakas S, Peterson CB, Rodon Ahnert J, Subbiah V, Karp DD, Stephen B, Hajjar J, Naing A. Colen RR, et al. J Immunother Cancer. 2021 Jul;9(7):e003299. doi: 10.1136/jitc-2021-003299. J Immunother Cancer. 2021. PMID: 34315823 Free PMC article.

Comment on

References

    1. Colen RR, Rolfo C, Ak M, et al. . Radiomics analysis for predicting pembrolizumab response in patients with advanced rare cancers. J Immunother Cancer 2021;9:e001752. 10.1136/jitc-2020-001752 - DOI - PMC - PubMed
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