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. 2021 Jul 7;3(7):1029-1031.
doi: 10.1016/j.jaccas.2021.04.013.

Pulmonary Tumor Thrombotic Microangiopathy as a Cause of Pulmonary Hypertension

Benjamin P Schwartz  1 , Philip Tracy  1 , Stephanie Hon  2 , Harrison W Farber  2 , James E Udelson  3
Affiliations

Pulmonary Tumor Thrombotic Microangiopathy as a Cause of Pulmonary Hypertension

Benjamin P Schwartz et al. JACC Case Rep. .

Abstract

Pulmonary tumor thrombotic microangiopathy is a rare entity, often diagnosed postmortem. We describe a patient with signs and symptoms of pulmonary hypertension secondary to metastatic cholangiocarcinoma with invasion of the myocardium and pulmonary vasculature, and highlight the diagnostic challenges and therapeutic limitations of this disease. (Level of Difficulty: Intermediate.).

Keywords: CTEPH; PTTM; PTTM, pulmonary tumor thrombotic microangiopathy; chronic thromboembolic pulmonary hypertension; pulmonary hypertension; pulmonary tumor thrombotic microangiopathy.

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Conflict of interest statement

The authors have reported that they have no relationships relevant to the contents of this paper to disclose.

Figures

None
Graphical abstract
Figure 1
Figure 1
Pulmonary Vasculature Invasion by Intrahepatic Cholangiocarcinoma Section of lung, with tumor cells in veins and lymphatic vessels (arrows).
See this image and copyright information in PMC

References

    1. Godbole R.H., Saggar R., Kamangar N. Pulmonary tumor thrombotic microangiopathy: a systematic review. Pulm Circ. 2019;9 2045894019851000. - PMC - PubMed
    1. D’Silva K., Vaidya A., Smithy J.W., Anderson W.J., Cockrill B. A rapid change in pressure. N Engl J Med. 2020;382:e8. - PubMed

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