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. 2021 Sep;110(3):559-562.
doi: 10.1002/cpt.2340. Epub 2021 Jul 28.

Advancing Precision Medicine Through the New Pharmacogenomics Global Research Network

Affiliations

Advancing Precision Medicine Through the New Pharmacogenomics Global Research Network

Kathleen M Giacomini et al. Clin Pharmacol Ther. 2021 Sep.

Abstract

The new Pharmacogenomics Global Research Network (PGRN) is an independent society that builds on the National Institutes of Health (NIH)–funded Pharmacogenomics Research Network that was established in 2000. Leveraging the original PGRN’s previous success, the new network continues to be a leader in the field of personalized medicine focusing on research, discovery, and translation of genomic variation influencing drug efficacy and adverse events, while simultaneously increasing inclusion in the field and expanding globally.

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Conflict of interest statement

CONFLICT OF INTEREST

A.A.M. is the current President of the PGRN and a member of the PGRN Board of Directors. J.J.Y. is the President-Elect and L.B.R. is the Treasurer-Elect of the PGRN. K.M.G. is a past president of the PGRN and a past member of the PGRN Board of Directors. All authors are PGRN members.

Figures

Figure 1
Figure 1
The PGRN provides multiple resources to its global community (a) Global map showing locations of PGRN members along with a list of specific countries in which members are located. PGRN, Pharmacogenomics Global Research Network. (b) PGx resources in the PGRN community. These resources are somewhat interdependent, and pharmacogenomic information flows across them consistently and transparently. PGRN, Pharmacogenomics Global Research Network; PGx, pharmacogenomics; PharmGKB, Pharmacogenomics Knowledge Base.

References

    1. Yang JJ et al. Inherited NUDT15 variant is a genetic determinant of mercaptopurine intolerance in children with acute lymphoblastic leukemia. J. Clin. Oncol 33, 1235–1242 (2015). - PMC - PubMed
    1. Milan DJ et al. Drug-sensitized zebrafish screen identifies multiple genes, including GINS3, as regulators of myocardial repolarization. Circulation 120, 553–559 (2009). - PMC - PubMed
    1. International Warfarin Pharmacogenetics Consortium et al. Estimation of the warfarin dose with clinical and pharmacogenetic data. N. Engl. J. Med 360, 753–764 (2009). - PMC - PubMed
    1. PGRN. Pharmacogenomics global research network <www.PGRN.org> (2020).
    1. Huddart R, Whirl-Carrillo M, Altman RB & Klein TE PharmGKB tutorial for pharmacogenomics of drugs potentially used in the context of COVID-19. Clin. Pharmacol. Ther 109, 116–122 (2021). - PMC - PubMed