Concurrent maternal malignancy and fetal trisomy detected using genome-wide noninvasive prenatal screening

Fergus Scott^{1

2}, Maria-Elisabeth Smet^{1

3}, Tristan Hardy⁴, Samantha Sundercombe⁵, Michael Friedlander^{2

6}, Louise Carey^{5

7}, Edwin Kirk^{5

7}, Biao Li⁸, Andrew McLennan^{1

9}

Affiliations

¹ Sydney Ultrasound for Women, Sydney, Australia.
² University of New South Wales, Sydney, Australia.
³ Fetal Medicine Unit, Westmead Hospital, Sydney, Australia.
⁴ Repromed, SA Pathology, Adelaide, Australia.
⁵ NSW Health Pathology Randwick Genomics, Randwick, Australia.
⁶ Department of Medical Oncology, Prince of Wales Clinical School, The Prince of Wales Hospital, Sydney, Australia.
⁷ School of Women's and Children's Health, UNSW, Sydney Children's Hospital, Randwick, Australia.
⁸ Department of Bioinformatics, Illumina Inc., San Diego, CA, USA.
⁹ Discipline of Obstetrics, Gynaecology and Neonatology, The University of Sydney, Sydney, Australia.

Fergus Scott et al. Prenat Diagn. 2021 Sep.

. 2021 Sep;41(10):1273-1276.

doi: 10.1002/pd.6020. Epub 2021 Aug 14.

Fergus Scott^{1

2}, Maria-Elisabeth Smet^{1

3}, Tristan Hardy⁴, Samantha Sundercombe⁵, Michael Friedlander^{2

6}, Louise Carey^{5

7}, Edwin Kirk^{5

7}, Biao Li⁸, Andrew McLennan^{1

9}

¹ Sydney Ultrasound for Women, Sydney, Australia.
² University of New South Wales, Sydney, Australia.
³ Fetal Medicine Unit, Westmead Hospital, Sydney, Australia.
⁴ Repromed, SA Pathology, Adelaide, Australia.
⁵ NSW Health Pathology Randwick Genomics, Randwick, Australia.
⁶ Department of Medical Oncology, Prince of Wales Clinical School, The Prince of Wales Hospital, Sydney, Australia.
⁷ School of Women's and Children's Health, UNSW, Sydney Children's Hospital, Randwick, Australia.
⁸ Department of Bioinformatics, Illumina Inc., San Diego, CA, USA.
⁹ Discipline of Obstetrics, Gynaecology and Neonatology, The University of Sydney, Sydney, Australia.

No abstract available

References

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1. Dharajiya N, Grosu D, Farkas D, et al. Incidental detection of maternal neoplasia in noninvasive prenatal testing. Clin Chem. 2018;64(2):329-335.
1. Carlson L, Hardisty E, Coombs C, Vora N. Maternal malignancy evaluation after discordant cell-free DNA results. Obstet Gynecol. 2018;131(3):464-468.
1. Cordeiro Mitchell CN, Murdock T, Fader AN, Stone RL. Advanced ovarian cancer treated in pregnancy and detected by cell-free DNA aneuploidy screening. Gynecol Oncol Rep. 2018;24:48-50.