Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Aug;34(4):289-297.
doi: 10.37201/req/087.2021. Epub 2021 Jul 28.

[Safety in the selection of oral antibiotic treatment in community infections, beyond COVID-19]

[Article in Spanish]
J Barberán  1 , L C Barberán, A de la Cuerda
Affiliations
Review

[Safety in the selection of oral antibiotic treatment in community infections, beyond COVID-19]

[Article in Spanish]
J Barberán et al. Rev Esp Quimioter. 2021 Aug.

Abstract
in English, Spanish

Oral antibiotics are among the most frequently used medications in the community. Its adverse effects are generally considered to be infrequent and mild, and include allergies, toxicities and drug interactions. Antibiotics are able to harm patients by various mechanisms, not always well known. Knowledge of the clinically relevant antibiotic-associated adverse effects can allow a judicious use based on the principle first do no harm, primun non nocere. In this review we explore the main adverse effects of oral antibiotics with specific focus on β-lactams, macrolides, and fluoroquinolones.

Los antibióticos orales son uno de los fármacos más utilizados en la comunidad. Sus efectos adversos son generalmente poco frecuentes y leves, e incluyen toxicidad e interacciones medicamentosas. El mecanismo de producción es variado y no siempre bien conocido. El conocimiento de los efectos adversos con relevancia clínica puede permitir hacer un uso más juicioso de los antibióticos basados en el principio primero no hacer daño, primun non nocere. En esta revisión exploramos los principales efectos adversos de los antibióticos orales con énfasis en los β-lactámicos, macrólidos y fluoroquinolonas.

Keywords: adverse effects; antibiotic drug interactions; cephalosporins; fluoroquinolones; macrolides; oral antibiotics; penicillins.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

  • Decalogue for the selection of oral antibiotics for lower respiratory tract infections.
    Cantón R, Barberán J, Linares M, Molero JM, Rodríguez-González-Moro JM, Salavert M, González Del Castillo J. Cantón R, et al. Rev Esp Quimioter. 2022 Feb;35(1):16-29. doi: 10.37201/req/172.2021. Epub 2022 Jan 19. Rev Esp Quimioter. 2022. PMID: 35041328 Free PMC article. Review.
  • Safety of fluoroquinolones.
    Barberán J, de la Cuerda A, Tejeda González MI, López Aparicio A, Monfort Vinuesa C, Ramos Sánchez A, Barberán LC. Barberán J, et al. Rev Esp Quimioter. 2024 Apr;37(2):127-133. doi: 10.37201/req/143.2023. Epub 2023 Dec 22. Rev Esp Quimioter. 2024. PMID: 38140798 Free PMC article. Review.

References

    1. Grayson ML, Cosgrove SE, Crowe SM, McCarthy JS, Hope W, Mills Jet al. . Principles of Antimicrobial Use. In: Grayson ML, et al. Eds. Kucer´s the use of antibiotics. A clinical review of antibacterial, antifungal, antiparasitic, and antiviral drugs. 7th ed. Boca Raton: CRC Press; 2017. p. 3-8.
    1. Smith CM. Origin and uses of primum non nocere–above all, do no harm!. J Clin Pharmacol 2005; 45:371–7; doi: 10.1177/0091270004273680 - DOI - PubMed
    1. Rolain JM, Baquero F. The refusal of the Society to accept antibiotic toxicity: missing opportunities for therapy of severe infections. Clin Microbiol Infect. 2016; 22:423-7. doi: 10.1016/j.cmi.2016.03.026. - DOI - PubMed
    1. Arulkumaran N, Routledge M, Schlebusch S, Lipman J, Conway Morris A. Antimicrobialassociated harm in critical care: a narrative review. Intensive Care Med 2020; 46:225–235. 10.1007/s00134-020-05929-3. - DOI - PMC - PubMed
    1. Pai MP, Momary KM; Rodvold KA. Antibiotic drug interactions. Med Clin North Am 2006; 90:1223-55. doi: 10.1016/j.mcna.2006.06.008. - DOI - PubMed

MeSH terms

Substances