Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021;38(2):e2021020.
doi: 10.36141/svdld.v38i2.10623. Epub 2021 Jun 28.

Original Article: Clinical Research

Gulay Dasdemir Ilkhan  1 , Fatma Demirci Üçsular  2 , Hakan Celikhisar  3 , Yücel Arman  4 , Enver Yalnız  2 , Tufan Tükek  5
Affiliations

Original Article: Clinical Research

Gulay Dasdemir Ilkhan et al. Sarcoidosis Vasc Diffuse Lung Dis. 2021.

Abstract

Aim: In this study, we aimed to investigate the possible role of endotrophin, a profibrotic byproduct of collagen VI, in the complex process of fibrosis development in the disease group with pulmonary fibrosis among interstitial lung diseases.

Material and method: When the patients' participation in the study were completed, smoking or alcohol drinking conditions, and family history were recorded. Their weights and heights were recorded and body mass index (BMI) was calculated. In every patient, Spirometry with bronchodilator testing, determination of single-breath DLCO, and plethysmographic measurement of thoracic gas volume and airway resistance were performed. Blood samples were obtained for the inflammation markers such as sedimentation rate, C-reactive protein (CRP), complete blood count, liver and renal function tests, and lactate dehydrogenase levels. Serum endotrophin levels were measured in all patients.

Results: Thirty-five patients with interstitial lung disease who were having pulmonary fibrosis, 35 patients with interstitial lung disease without pulmonary fibrosis, and 20 control patients without any signs or symptoms of interstitial lung disease were included in the study. Age distribution was similar between groups. The fibrotic ILD group was more commonly smoker or ex-smoker compared with the non-fibrotic ILD patients or control cases. Fibrotic ILD patients were leaner, having significantly decreased total lung capacity, diffusion capacity, and higher LDH levels. In the comparison of the 3 study groups regarding the endotrophin levels, there was a significant difference between groups. The fibrotic and non-fibrotic patient groups were compared for the Endotrophin levels and the difference was also significant. However, there was not any significant difference regarding the endotrophin levels between control cases and non-fibrotic ILD patients. Smoked cigarette pocket x year showed a significant positive correlation and DLCO % and KCO % showed a significant negative correlation with the endotrophin levels.

Conclusion: Serum endotrophin levels significantly increase in fibrotic ILD patients compared with the non-fibrotic ILD patients and control cases. Endotrophin may be suggested as a diagnostic marker in fibrotic interstitial lung diseases.

Keywords: Endotrophin; interstitial lung disease; plethysmography; pulmonary fibrosis.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Dot plot showing the distribution of serum Endotrophin levels between groups
Figure 2.
Figure 2.
ROC curve for serum endotrophin level in fibrotic and non-fibrotic ILD differentiation
See this image and copyright information in PMC

References

    1. Kishaba T. Evaluation and management of Idiopathic Pulmonary Fibrosis. Respir Investig. 2019 Jul;57(4):300–311. - PubMed
    1. Meyer KC. Pulmonary fibrosis, part I: epidemiology, pathogenesis, and diagnosis. Expert Rev Respir Med. 2017 May;11(5):343–359. - PubMed
    1. Wurmann P, Sabugo F, Elgueta F, Mac-Namara M, Vergara K, Vargas D, Molina ML, Díaz JC, Gatica H, Goecke A. Interstitial lung disease and microscopic polyangiitis in chilean patients. Sarcoidosis Vasc Diffuse Lung Dis. 2020;37(1):37–42. - PMC - PubMed
    1. Guo J, Yang Z, Jia Q, Bo C, Shao H, Zhang Z. Pirfenidone inhibits epithelial-mesenchymal transition and pulmonary fibrosis in the rat silicosis model. Toxicol Lett. 2019 Jan;300:59–66. - PubMed
    1. Redente EF, Aguilar MA, Black BP, Edelman BL, Bahadur AN, Humphries SM, Lynch DA, Wollin L, Riches DWH. Nintedanib reduces pulmonary fibrosis in a model of rheumatoid arthritis-associated interstitial lung disease. Am J Physiol Lung Cell Mol Physiol. 2018 Jun 1;314(6):L998–L1009. - PMC - PubMed

LinkOut - more resources