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. 2021 Nov;39(6):1091-1100.
doi: 10.1007/s00774-021-01255-w. Epub 2021 Jul 28.

Replacing sedentary time for physical activity on bone density in patients with chronic kidney disease

Masaki Yoshioka  1   2 , Keisei Kosaki  3 , Masahiro Matsui  1   2 , Ai Shibata  3 , Koichiro Oka  4 , Makoto Kuro-O  5 , Chie Saito  6 , Kunihiro Yamagata  6   7 , Seiji Maeda  8   9
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Replacing sedentary time for physical activity on bone density in patients with chronic kidney disease

Masaki Yoshioka et al. J Bone Miner Metab. 2021 Nov.

Abstract

Introduction: This study aimed to examine the cross-sectional associations of sedentary time and physical activity time with bone density in patients with chronic kidney disease (CKD). The isotemporal substitution (IS) modeling was used to estimate the beneficial effects of behavioral changes (e.g., replacing sedentary time with physical activity time) on bone density in these patients.

Materials and methods: A total of 92 patients with CKD (age: 65 ± 9 years; estimated glomerular filtration rate: 57 ± 22 mL/min/1.73 m2) were included in this cross-sectional study. The times spent in sedentary behavior (SB), light-intensity physical activity (LPA), and moderate- to vigorous-intensity physical activity (MVPA) were assessed using a triaxial accelerometer. Through quantitative ultrasound measurements, the stiffness index, as a measure of bone density, was calculated using the speed of sound and broadband ultrasound attenuation.

Results: In multivariate analyses, the stiffness index was beneficially associated with the MVPA time (β = 0.748), but was not significantly associated with the SB and LPA times. The IS models showed that replacing 10 min/day of SB with the equivalent LPA time was not significantly associated with the stiffness index; however, replacing 10 min/day of SB with the equivalent MVPA time was beneficially associated with the stiffness index (β = 0.804).

Conclusion: These results suggest that a small increase in MVPA time (e.g., 10 min/day) may attenuate the decline in bone density in patients with CKD. Our findings may provide insight for the development of novel strategies for improving bone health in patients with CKD.

Keywords: Bone health; Isotemporal substitution; Physical activity time; Renal dysfunction; Sedentary time.

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References

    1. Isakova T, Nickolas TL, Denburg M et al (2017) KDOQI US commentary on the 2017 KDIGO clinical practice guideline update for the diagnosis, evaluation, prevention, and treatment of chronic kidney disease-mineral and bone disorder (CKD-MBD). Am J Kidney Dis 70:737–751. https://doi.org/10.1053/j.ajkd.2017.07.019 - DOI - PubMed
    1. Zheng CM, Zheng JQ, Wu CC et al (2016) Bone loss in chronic kidney disease: quantity or quality? Bone 87:57–70 - DOI
    1. Kuipers AL, Egwuogu H, Evans RW et al (2015) Renal function and bone loss in a cohort of Afro-Caribbean men. J Bone Miner Res 30:2215–2220. https://doi.org/10.1002/jbmr.2562 - DOI - PubMed
    1. Prasad B, Ferguson T, Tangri N et al (2019) Association of bone mineral density with fractures across the spectrum of chronic kidney disease: the regina CKD-MBD study. Can J Kidney Heal Dis. https://doi.org/10.1177/2054358119870539 - DOI
    1. Iseri K, Dai L, Chen Z et al (2020) Bone mineral density and mortality in end-stage renal disease patients. Clin Kidney J. https://doi.org/10.1093/ckj/sfaa089 - DOI - PubMed - PMC

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