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Review
. 2021 Nov;476(11):4161-4166.
doi: 10.1007/s11010-021-04232-z. Epub 2021 Jul 28.

The potential role of neopterin in Covid-19: a new perspective

Hayder M Al-Kuraishy  1 , Ali I Al-Gareeb  1 , Khalid J Alzahrani  2 , Natália Cruz-Martins  3   4   5 , Gaber El-Saber Batiha  6
Affiliations
Review

The potential role of neopterin in Covid-19: a new perspective

Hayder M Al-Kuraishy et al. Mol Cell Biochem. 2021 Nov.

Abstract

Neopterin (NPT) is a member of pteridines group, synthesized by macrophages when stimulated by interferon gamma (INF-γ). NPT is regarded as a macrophage stimulation indicator, marker of cellular immune activation and T helper 1 (Th1) type 1 immune response. Here, we aimed to provide a view point on the NPT features and role in Covid-19. Serum NPT level is regarded as an independent prognostic factor for Covid-19 severity, with levels starting to increase from the 3rd day of SARS-CoV-2 infection, being associated with severe dyspnea, longer hospitalization period and complications. Also, early raise of NPT reflects monocytes/macrophages activation before antibody immune response, despite the NPT level may also remain high in Covid-19 patients or at the end of incubation period before the onset of clinical symptoms. On the other hand, NPT attenuates the activity of macrophage foam cells and is linked to endothelial inflammation through inhibition of adhesion molecules and monocytes migration. However, NPT also exerts anti-inflammatory and antioxidant effects by suppressing NF-κB signaling and NLRP3 inflammasomes. NPT can be viewed as a protective compensatory mechanism to counterpoise hyper-inflammation, oxidative stress, and associated organ damage.

Keywords: Covid-19 severity; Neopterin; SARS-CoV-2 infection.

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Conflict of interest statement

The authors declare that there are no conflict of interest.

Figures

Fig. 1
Fig. 1
Activation of neopterin release and inhibition of adhesion molecules: T cells through tumor necrosis alpha (TNF-α), natural killer (NK) cells through interferon gamma (INF-γ) and viral infections through pathogen-associated molecular patterns (PAMPs) activate macrophage (M1) for release of neopterin (NPT), which inhibit release of adhesion molecules, monocyte chemoattractant protein-1 (MCP-1), intracellular adhesion molecule-1(ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1)
Fig. 2
Fig. 2
The potential role of neopterin in SARS-CoV-2 infection: Neopterin (NPT) inhibits tissue injury, hyperinflammation and oxidative stress that are induced by SARS-CoV-2-mediated immune activation
See this image and copyright information in PMC

References

    1. Al-Kuraishy HM, Al-Naimi MS, Lungnier CM, Al-Gareeb AI. Macrolides and COVID-19: an optimum premise. Biomed Biotechnol Res J. 2020;4(3):189. doi: 10.4103/bbrj.bbrj_103_20. - DOI
    1. Al-Kuraishy HM, Hussien NR, Al-Naimi MS, Al-Buhadily AK, Al-Gareeb AI, Lungnier C. Renin-Angiotensin system and fibrinolytic pathway in COVID-19: one-way skepticism. Biomed Biotechnol Res J. 2020;4(5):33.
    1. Al-Kuraishy HM, Al-Gareeb AI, Qusty N, Cruz-Martins N, Batiha GE. Sequential doxycycline and colchicine combination therapy in Covid-19: the salutary effects. Pulm Pharmacol Ther. 2021;67:102008. doi: 10.1016/j.pupt.2021.102008. - DOI - PMC - PubMed
    1. Al-Kuraishy HM, Al-Niemi MS, Hussain NR, Al-Gareeb AI, Al-Harchan NA, Al-Kurashi AH. The potential role of renin angiotensin system (RAS) and dipeptidyl peptidase-4 (DPP-4) in COVID-19: navigating the uncharted. In: Kibel A, editor. Selected chapters from the reninangiotensin system. London: IntechOpen; 2020. pp. 151–165.
    1. Al-Kuraishy HM, Al-Gareeb AI, Alblihed M, Cruz-Martins N, Batiha GE. COVID-19 and risk of acute ischemic stroke and acute lung injury in patients with type II diabetes mellitus: the anti-inflammatory role of metformin. Front Med. 2021;8:110. doi: 10.3389/fmed.2021.644295. - DOI - PMC - PubMed