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. 2022 Jan;85(1):44-55.
doi: 10.1002/jemt.23883. Epub 2021 Jul 28.

Elucidating the structural, anticancer, and antibacterial traits of Punica granatum peel extracts-mediated Ag and Ag/GO nanocomposites

Emima Jeronsia J  1 , Ragu R  2 , Jerline Mary A  2 , Jerome Das S  2
Affiliations

Elucidating the structural, anticancer, and antibacterial traits of Punica granatum peel extracts-mediated Ag and Ag/GO nanocomposites

Emima Jeronsia J et al. Microsc Res Tech. 2022 Jan.

Abstract

Ag nanoparticles and Ag/GO nanocomposites have been synthesized by facile, eco-friendly, and cost-effective green approach using the peel extracts of Punica granatum. The synthesized Silver Nanoparticles and Silver Graphene Oxide nanocomposites were characterized by UV-visible spectroscopy, X-ray diffraction, transmission electron microscopy, and Fourier transform infrared analysis. AgNPs revealed spherical morphology with particle size ranging from 30 to 40 nm. Scanning electron microscopy results revealed silver nanoparticles with an average size of 35 nm being uniformly distributed over GO sheets. The surface plasmon band appears at 433 nm for AgNPs and 458 nm for Ag/GO nanocomposites. The green synthesized nanoparticles were found to have excellent antibacterial efficacy against both gram positive (Staphylococcus aureus, Bacillus subtilis) and gram negative (Klebsiella pneumoniae, Escherichia coli) bacterial strains. The results showed that Ag/GO nanocomposites showed better antibacterial activity than pure AgNPs with maximum inhibitory zone of 28 mm for Escherichia coli. This attributes to the role of GO sheets in preventing AgNPs from agglomerating and oxidizing. The anticancer activity of AgNPs and Ag/GO nanocomposites were tested against human breast cancer cell line (MCF-7) which demonstrated a dose dependent activity with half minimum inhibitory concentration of 100 and 150 μg/ml.

Keywords: Ag/GO nanocomposites; antibacterial activity; anticancer activity; fruit peel extract; silver nanoparticles.

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References

REFERENCES

    1. Ahmad, A., Mukherjee, P., Senapati, S., Mandal, D., Khan, M. I., Kumar, R., & Sastry, M. (2003). Extracellular biosynthesis of silver nanoparticles using the fungus Fusarium oxysporum. Colloids and Surfaces B: Biointerfaces, 28(4), 313-318.
    1. Al-Rawahi, A. S., Edwards, G., Al-Sibani, M., Al-Thani, G., Al-Harrasi, A. S., & Rahma, M. S. (2014). Phenolic constituents of pomegranate peels (Punica granatum L.) cultivated in Oman. European Journal of Medicinal Plants, 4(3), 315-331.
    1. Al-Saadi, N. H. M., Ahmad, N. S., & Ebraheem Sáeed, S. (2009). Determination of some chemical compounds and the effect of oil extract from orange peel on some pathogens. Journal of Kerbala University, 7, 33-39.
    1. Bankar, A., Joshi, B., Kumara, A. R., & Zinjarde, S. (2010). Banana peel extract mediated novel route for the synthesis of silver nanoparticles. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 368, 58-63.
    1. Bhui, D. K., Sahoo, G. P., Sarkar, P., Pyne, S., & Misra, A. (2009). Green synthesis of silver nanoparticles using seed extract of Jatropha curcas. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 348, 212-216.

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