Intranasal esketamine and the dawn of precision psychiatry

doi:10.1590/1516-4446-2021-0031

Editorial

. 2022 Mar-Abr;44(2):117-118.

doi: 10.1590/1516-4446-2021-0031.

Intranasal esketamine and the dawn of precision psychiatry

Devon Watts^{1

2}, Frederico D Garcia³, Acioly L T Lacerda^{4

5

6

7}, Jair de J Mari⁸, Lucas C Quarantini^{9

10}, Flávio Kapczinski^{1

2

7

11}

Affiliations

¹ St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada.
² Neuroscience Graduate Program, McMaster University, Hamilton, ON, Canada.
³ Departamento de Saúde Mental, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.
⁴ Programa deTranstornos Afetivos (PRODAF), Departamento de Psiquiatria, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.
⁵ Laboratório Interdisciplinar de Neurociências Clínicas (LiNC), UNIFESP, São Paulo, SP, Brazil.
⁶ Instituto Nacional de Ciência e Tecnologia Translacional em Medicina (INCT-TM), Brazil.
⁷ CNS Unit, BR Trials, São Paulo, SP, Brazil.
⁸ Departamento de Psiquiatria, UNIFESP, São Paulo, SP, Brazil.
⁹ Laborato´ rio de Neuropsicofarmacologia, Servic¸o de Psiquiatria, Hospital Universita´ rio Professor Edgard Santos, Universidade Federal da Bahia (UFBA), Salvador, BA, Brazil.
¹⁰ Departamento de Neurociências e Saúde Mental, Faculdade de Medicina da Bahia, UFBA, Salvador, BA, Brazil.
¹¹ Department of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, ON, Canada.

PMID: 34320126
PMCID: PMC9041972
DOI: 10.1590/1516-4446-2021-0031

Editorial

Intranasal esketamine and the dawn of precision psychiatry

Devon Watts et al. Braz J Psychiatry. 2022 Mar-Abr.

. 2022 Mar-Abr;44(2):117-118.

doi: 10.1590/1516-4446-2021-0031.

Authors

Devon Watts^{1

2}, Frederico D Garcia³, Acioly L T Lacerda^{4

5

6

7}, Jair de J Mari⁸, Lucas C Quarantini^{9

10}, Flávio Kapczinski^{1

2

7

11}

Affiliations

¹ St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada.
² Neuroscience Graduate Program, McMaster University, Hamilton, ON, Canada.
³ Departamento de Saúde Mental, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.
⁴ Programa deTranstornos Afetivos (PRODAF), Departamento de Psiquiatria, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.
⁵ Laboratório Interdisciplinar de Neurociências Clínicas (LiNC), UNIFESP, São Paulo, SP, Brazil.
⁶ Instituto Nacional de Ciência e Tecnologia Translacional em Medicina (INCT-TM), Brazil.
⁷ CNS Unit, BR Trials, São Paulo, SP, Brazil.
⁸ Departamento de Psiquiatria, UNIFESP, São Paulo, SP, Brazil.
⁹ Laborato´ rio de Neuropsicofarmacologia, Servic¸o de Psiquiatria, Hospital Universita´ rio Professor Edgard Santos, Universidade Federal da Bahia (UFBA), Salvador, BA, Brazil.
¹⁰ Departamento de Neurociências e Saúde Mental, Faculdade de Medicina da Bahia, UFBA, Salvador, BA, Brazil.
¹¹ Department of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, ON, Canada.

PMID: 34320126
PMCID: PMC9041972
DOI: 10.1590/1516-4446-2021-0031

No abstract available

PubMed Disclaimer

Conflict of interest statement

FDG has received personal fees from Pfizer and Janssen-Cilag. ALTL has received consulting fees from Janssen Pharmaceutical, Daiichi Sankyo, Cristalia Produtos Químicos e Farmacêuticos, Pfizer, Mantecorp Indústria Química e Farmacêutica, Libbs Farmacêutica, FQM Farma, and Sanofi-Aventis; and has received research fees from Janssen Pharmaceutical, Eli Lilly, H. Lundbeck A/S, Servier Laboratories, Biophytis, Novo Nordisk, Genentech, Hoffman-La Roche, FQM Farma, and Forum Pharmaceuticals. LCQ has received consulting fees from Allergan, Abbot, Cristalia, Janssen Pharmaceutical, and Lundbeck; and has received research fees from Janssen Pharmaceutical. FK has received personal fees from Daiichi Sankyo and Janssen-Cilag. The other authors report no conflicts of interest.

Cited by

Not only pharmacodynamic: the role of brain circuits in improving the treatment of suicidal thoughts and behaviors.
Damiano RF, Miguel EC, Shephard E. Damiano RF, et al. Braz J Psychiatry. 2022 Jan-Feb;44(1):113. doi: 10.1590/1516-4446-2021-2257. Braz J Psychiatry. 2022. PMID: 35170674 Free PMC article. No abstract available.

References

1. Steel Z, Marnane C, Iranpour C, Chey T, Jackson JW, Patel V, et al. The global prevalence of common mental disorders: a systematic review and meta-analysis 1980 – 2013. Int J Epidemiol. 2014;43:476–93. - PMC - PubMed
1. Merikangas KR, Jin R, He JP, Kessler RC, Lee S, Sampson NA, et al. Prevalence and correlates of bipolar spectrum disorder in the world mental health survey initiative. Arch Gen Psychiatry. 2011;68:241–51. - PMC - PubMed
1. Hyman SE. Psychiatric drug development: diagnosing a crisis. Cerebrum. 2013;2013:5. - PMC - PubMed
1. Kennedy SH, Lam RW, McIntyre RS, Tourjman SV, Bhat V, Blier P, et al. Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 clinical guidelines for the management of adults with major depressive disorder: section 3. Pharmacological treatments. Can J Psychiatry. 2016;61:540–60. - PMC - PubMed
1. Rush AJ, Trivedi MH, Wisniewski SR, Nierenberg AA, Stewart JW, Warden D, et al. Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps. Am J Psychiatry. 2006;163:1905–17. - PubMed

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[1] Steel Z, Marnane C, Iranpour C, Chey T, Jackson JW, Patel V, et al. The global prevalence of common mental disorders: a systematic review and meta-analysis 1980 – 2013. Int J Epidemiol. 2014;43:476–93. - PMC - PubMed

[2] Steel Z, Marnane C, Iranpour C, Chey T, Jackson JW, Patel V, et al. The global prevalence of common mental disorders: a systematic review and meta-analysis 1980 – 2013. Int J Epidemiol. 2014;43:476–93. - PMC - PubMed

[3] Merikangas KR, Jin R, He JP, Kessler RC, Lee S, Sampson NA, et al. Prevalence and correlates of bipolar spectrum disorder in the world mental health survey initiative. Arch Gen Psychiatry. 2011;68:241–51. - PMC - PubMed

[4] Merikangas KR, Jin R, He JP, Kessler RC, Lee S, Sampson NA, et al. Prevalence and correlates of bipolar spectrum disorder in the world mental health survey initiative. Arch Gen Psychiatry. 2011;68:241–51. - PMC - PubMed

[5] Hyman SE. Psychiatric drug development: diagnosing a crisis. Cerebrum. 2013;2013:5. - PMC - PubMed

[6] Hyman SE. Psychiatric drug development: diagnosing a crisis. Cerebrum. 2013;2013:5. - PMC - PubMed

[7] Kennedy SH, Lam RW, McIntyre RS, Tourjman SV, Bhat V, Blier P, et al. Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 clinical guidelines for the management of adults with major depressive disorder: section 3. Pharmacological treatments. Can J Psychiatry. 2016;61:540–60. - PMC - PubMed

[8] Kennedy SH, Lam RW, McIntyre RS, Tourjman SV, Bhat V, Blier P, et al. Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 clinical guidelines for the management of adults with major depressive disorder: section 3. Pharmacological treatments. Can J Psychiatry. 2016;61:540–60. - PMC - PubMed

[9] Rush AJ, Trivedi MH, Wisniewski SR, Nierenberg AA, Stewart JW, Warden D, et al. Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps. Am J Psychiatry. 2006;163:1905–17. - PubMed

[10] Rush AJ, Trivedi MH, Wisniewski SR, Nierenberg AA, Stewart JW, Warden D, et al. Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps. Am J Psychiatry. 2006;163:1905–17. - PubMed

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Intranasal esketamine and the dawn of precision psychiatry

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Intranasal esketamine and the dawn of precision psychiatry

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