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Review
. 2021 Jul 12:12:710044.
doi: 10.3389/fimmu.2021.710044. eCollection 2021.

Can Broadly Neutralizing HIV-1 Antibodies Help Achieve an ART-Free Remission?

Denise C Hsu  1   2 , John W Mellors  3 , Sandhya Vasan  1   2
Affiliations
Review

Can Broadly Neutralizing HIV-1 Antibodies Help Achieve an ART-Free Remission?

Denise C Hsu et al. Front Immunol. .

Abstract

Many broadly neutralizing antibodies (bnAbs) targeting the HIV-1 envelope glycoprotein are being assessed in clinical trials as strategies for HIV-1 prevention, treatment, and antiretroviral-free remission. BnAbs can neutralize HIV-1 and target infected cells for elimination. Concerns about HIV-1 resistance to single bnAbs have led to studies of bnAb combinations with non-overlapping resistance profiles. This review focuses on the potential for bnAbs to induce HIV-1 remission, either alone or in combination with latency reversing agents, therapeutic vaccines or other novel therapeutics. Key topics include preliminary activity of bnAbs in preclinical models and in human studies of HIV-1 remission, clinical trial designs, and antibody design strategies to optimize pharmacokinetics, coverage of rebound-competent virus, and enhancement of cellular immune functions.

Keywords: HIV cure; HIV immunotherapy; HIV remission; HIV therapeutics; broadly neutralizing HIV-1 antibody.

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Conflict of interest statement

SV and DH report grants from the U.S. Department of Defense with Henry M. Jackson Foundation for the Advancement of Military Medicine and grants from the NIH/NIAID for the submitted work. SV also report grants from the U.S. Department of Defense. JM reports grants from the NIH for the submitted work, and grants from Gilead Sciences, Janssen Pharmaceuticals, USAID, and personal fees from Accelevir Diagnostics, Gilead Sciences, Merck, Xi’an Yufan Biotechnologies, and other from Infectious Diseases Connect, Co-Crystal Pharmaceuticals, Inc., and Abound Bio, Inc., outside the submitted work.

Figures

Figure 1
Figure 1
Anti-HIV-1 broadly neutralizing antibodies in clinical trials and their targets on the HIV-1 envelope.
See this image and copyright information in PMC

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