Gilbert's Syndrome With Diabetes Mellitus

Abstract

Gilbert's syndrome (GS) could lead to the high bilirubin, and gestational diabetes mellitus might reverse this index. A primigravida with a pregnancy of 38 weeks and 4 days was identified having gestational diabetes mellitus (GDM) with Gilbert's syndrome. General laboratory tests were normal except mild unconjugated hyperbilirubinaemia and hyperglycemia. The delivery process was going well with completely delivered placenta and fetal membrane, and I° turbid amniotic fluid. The newborn was noted to have high bilirubin level which reversed after a few days of treatment. Gilbert's syndrome is rare in obstetric practice with the virtually decreased activity of uridine diphosphate glucuronosyl transferase (UDPGT). This is the first report to confirm that pregnant women with Gilbert's syndrome and gestational diabetes could give birth normally without significant adverse symptoms, except for jaundice.

Keywords: diabetes mellitus; gdm; gilbert’s syndrome; hyperbilirubinemia; pregnancy.