Alzheimer's disease: the controversial approval of Aducanumab
- PMID: 34322762
- DOI: 10.1007/s10072-021-05497-4
Alzheimer's disease: the controversial approval of Aducanumab
Comment in
-
More on aducanumab.Neurol Sci. 2022 Jan;43(1):713-714. doi: 10.1007/s10072-021-05663-8. Epub 2021 Oct 14. Neurol Sci. 2022. PMID: 34648104 No abstract available.
References
-
- Hardy JA, Higgins GA (1992) Alzheimer’s disease: the amyloid cascade hypothesis. Science 256(5054):184–185. https://doi.org/10.1126/science.1566067 - DOI - PubMed
-
- Panza F, Lozupone M, Logroscino G, Imbimbo BP (2019) A critical appraisal of amyloid-beta-targeting therapies for Alzheimer disease. Nat Rev Neurol 15:73–88. https://doi.org/10.1038/s41582-018-0116-6 - DOI - PubMed
-
- FDA. FDA’s decision to approve new treatment for Alzheimer’s disease. 2021 Jul 6 [cited 2021 Jun 14]. Available from: https://www.fda.gov/drugs/news-events-human-drugs/fdas-decision-approve-... . Accessed 21 Jul 2021
-
- Sevigny J, Chiao P, Bussière T, Weinreb PH, Williams L et al (2016) The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease. Nature 537(7618):50–56. https://doi.org/10.1038/nature19323 - DOI - PubMed - PMC
-
- Biogen (2019) EMERGE and EMERGE and ENGAGE topline results: two phase 3 studies to evaluate aducanumab in patients with early Alzheimer’s disease. Available from: https://investors.biogen.com/static-files/ddd45672-9c7e-4c99-8a06-3b5576... . Accessed 21 Jul 2021
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical