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Review
. 2021 Jul;52(4):548-554.
doi: 10.12182/20210760301.

[Role of Stem Cells and Their Biomimetic Matrix Microenvironment in Regenerative Repair of Articular Cartilage: A Review]

[Article in Chinese]
Hong-Fu Cao  1   2 , Zhu-Lian Li  1   2 , Yong Sun  1   2 , Yu-Jiang Fan  1   2 , Xing-Dong Zhang  1   2
Affiliations
Review

[Role of Stem Cells and Their Biomimetic Matrix Microenvironment in Regenerative Repair of Articular Cartilage: A Review]

[Article in Chinese]
Hong-Fu Cao et al. Sichuan Da Xue Xue Bao Yi Xue Ban. 2021 Jul.

Abstract
in English, Chinese

It is difficult for the articular cartilage to self-heal any damage it may incur due to its lack of nerves and blood vessels. Development in stem cell technology provides new prospects for articular cartilage regeneration. Currently, stem cells from different sources and their diverse applications have demonstrated different degrees of therapeutic effect and potential in articular cartilage repair. However, stem cells are highly sensitive to their microenvironment. Therefore, more and more researchers are focusing their attention on regulating stem cells and thus accelerating cartilage regeneration through the biomimetic microenvironment constructed by biologically functional scaffolds. We reviewed in this paper the sources of the stem cells used for cartilage repair, the application method of these stem cells, as well as the therapeutic effect, mechanism and limitations in the application of stem cells synergizing with the biomimetic microenvironment in promoting articular cartilage repair and regeneration. We hoped to provide suggestions for practical clinical research in the design and improvement of biofunctional cartilage repair scaffolds that synergize with stem cells.

关节软骨由于无神经、无血管的特性，一旦损伤，其自我修复十分困难。干细胞技术的发展为关节软骨再生提供了新的希望。当前，不同来源的干细胞及多种应用方式在关节软骨修复中展现出不同程度的治疗效果。然而，干细胞对其所处的微环境均有极强的敏感性，这使得越来越多的研究者开始关注通过生物功能性支架构建的仿生微环境来调控干细胞，进而加速软骨再生。本文主要讨论了软骨修复的干细胞来源、其应用手段及其协同仿生细胞微环境在关节软骨修复方面的治疗效果、机制和应用不足。希望对协同干细胞的功能性软骨修复支架的设计和优化提供更加切实的临床化研究思路。

Keywords: Articular cartilage repair; Biofunctional scaffold materials; Biomimetic microenvironment; Stem cell.

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Conflict of interest statement

利益冲突 所有作者均声明不存在利益冲突

Figures

图 1
图 1
Three elements of tissue engineering articular cartilage 组织工程关节软骨三要素
图 2
图 2
Application of scaffold-free stem cells in articular cartilage repair 无支架干细胞应用于关节软骨修复的方式
See this image and copyright information in PMC

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