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Review
. 2022 Mar 2;116(3):201-212.
doi: 10.1093/trstmh/trab114.

Broadening the range of use cases for ivermectin - a review of the evidence

Christian Kositz  1 , John Bradley  2 , Harry Hutchins  1 , Anna Last  1   3 , Umberto D'Alessandro  4 , Michael Marks  1   3
Affiliations
Review

Broadening the range of use cases for ivermectin - a review of the evidence

Christian Kositz et al. Trans R Soc Trop Med Hyg. .

Abstract

Ivermectin is a broad-spectrum antiparasitic agent that interferes with glutamate-gated chloride channels found in invertebrates but not in vertebrate species. Mass drug administration (MDA) with ivermectin-based regimes has been a mainstay of elimination efforts targeting onchocerciasis and lymphatic filariasis for more than 3 decades. More recently, interest in the use of ivermectin to control other neglected tropical diseases (NTDs) such as soil-transmitted helminths and scabies has grown. Interest has been further stimulated by the fact that ivermectin displays endectocidal efficacy against various Anopheles species capable of transmitting malaria. Therefore there is growing interest in using ivermectin MDA as a tool that might aid in the control of both malaria and several NTDs. In this review we outline the evidence base to date on these emerging indications for ivermectin MDA with reference to clinical and public health data and discuss the rationale for evaluating the range of impacts of a malaria ivermectin MDA on other NTDs.

Keywords: ivermectin; malaria; mass drug administration; neglected tropical diseases; soil-transmitted helminths.

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References

    1. Omura S, Crump A. The life and times of ivermectin—a success story. Nat Rev Microbiol. 2004;2:(12):984–9. - PubMed
    1. McArthur MJ, Reinemeyer CR. Herding the U.S. cattle industry toward a paradigm shift in parasite control. Vet Parasitol. 2014;204(1–2):34–43. - PubMed
    1. Burgess CGS, Bartley Y, Redman Eet al. A survey of the trichostrongylid nematode species present on UK sheep farms and associated anthelmintic control practices. Vet Parasitol. 2012;189(2–4):299–307. - PubMed
    1. Chabala JC, Mrozik H, Tolman RLet al. Ivermectin, a new broad-spectrum antiparasitic agent. J Med Chem. 1980;23(10):1134–6. - PubMed
    1. Glaziou P, Cartel JL, Alzieu Pet al. Comparison of ivermectin and benzyl benzoate for treatment of scabies. Trop Med Parasitol. 1993;44(4):331–2. - PubMed

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