Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2022 Feb;35(1):94-101.
doi: 10.1111/jhn.12935. Epub 2021 Sep 5.

A new palatable oral rehydration solution: A randomised controlled cross-over study in patients with a high output stoma

Alison Culkin  1 , Simon M Gabe  1 , Jeremy M D Nightingale  1
Affiliations
Randomized Controlled Trial

A new palatable oral rehydration solution: A randomised controlled cross-over study in patients with a high output stoma

Alison Culkin et al. J Hum Nutr Diet. 2022 Feb.

Abstract

Background: Patients with a jejunostomy or high output stoma may need a glucose-sodium oral rehydration solution drink to maintain hydration. These solutions are unpalatable and a new flavoured pre-packaged solution was developed.

Methods: After 8 h of fasting, 27 patients took 500 mL of the modified World Health Organization (WHO) cholera solution or Glucodrate® (Vitaflo) on two occasions in a cross-over random order and urine and stomal output was collected for 6 h.

Results: There was a small but significant difference in net sodium absorption in favour of the modified WHO cholera solution (10 ± 28 mmol modified WHO cholera solution vs. -1 ± 26 mmol Glucodrate®, p = 0.01). However the Glucodrate® was more palatable, with 24 patients (89%) preferring it to the modified WHO cholera solution (p < 0.005).

Conclusions: Glucodrate® is a more palatable solution than the modified WHO cholera solution and is almost as effective and so can be used when patients find the modified WHO cholera solution unpalatable.

Keywords: high output stoma; ileostomy; jejunostomy; oral rehydration solution; palatability.

PubMed Disclaimer

References

REFERENCES

    1. Baker ML, Williams RN, Nightingale JM. Causes and management of a high-output stoma. Colorectal Dis. 2011;13:191-7.
    1. Nightingale JMD, Woodward JM. Guidelines for the management of patients with a short bowel. Gut. 2006;55:1-12.
    1. Messaris E, Sehgal R, Deiling S, Koltun WA, Stewart D, McKenna K, et al. Dehydration is the most common indication for readmission after diverting ileostomy creation. Dis Colon Rectum. 2012;55:175-80.
    1. Lennard-Jones JE. Review article: practical management of the short bowel. Aliment Pharmacol Ther. 1994;8:563-77.
    1. Nightingale JM, Lennard-Jones JE, Walker ER, Farthing MJ. Jejunal efflux in short bowel syndrome. Lancet. 1990;336:765-8.

Publication types

LinkOut - more resources