On the causal relationships between hyperinsulinaemia, insulin resistance, obesity and dysglycaemia in type 2 diabetes: Reply to Johnson JD [letter]

Nathalie Esser^{1

2}, Kristina M Utzschneider^{1

2}, Steven E Kahn^{3

4}

Affiliations

¹ Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA.
² Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA.
³ Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA. skahn@uw.edu.
⁴ Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA. skahn@uw.edu.

Comment

Nathalie Esser et al. Diabetologia. 2021 Oct.

. 2021 Oct;64(10):2345-2347.

doi: 10.1007/s00125-021-05511-6. Epub 2021 Jul 29.

Nathalie Esser^{1

2}, Kristina M Utzschneider^{1

2}, Steven E Kahn^{3

4}

¹ Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA.
² Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA.
³ Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA. skahn@uw.edu.
⁴ Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA. skahn@uw.edu.

No abstract available

Keywords: Beta cell function; Dysglycaemia; Glucose effectiveness; Hyperinsulinaemia; Insulin resistance; Obesity; Type 2 diabetes.

Comment on

Early beta cell dysfunction vs insulin hypersecretion as the primary event in the pathogenesis of dysglycaemia.
Esser N, Utzschneider KM, Kahn SE. Esser N, et al. Diabetologia. 2020 Oct;63(10):2007-2021. doi: 10.1007/s00125-020-05245-x. Epub 2020 Sep 7. Diabetologia. 2020. PMID: 32894311 Review.
On the causal relationships between hyperinsulinaemia, insulin resistance, obesity and dysglycaemia in type 2 diabetes.
Johnson JD. Johnson JD. Diabetologia. 2021 Oct;64(10):2138-2146. doi: 10.1007/s00125-021-05505-4. Epub 2021 Jul 22. Diabetologia. 2021. PMID: 34296322

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1. Esser N, Utzschneider KM, Kahn SE (2020) Early beta cell dysfunction vs insulin hypersecretion as the primary event in the pathogenesis of dysglycaemia. Diabetologia 63(10):2007–2021. https://doi.org/10.1007/s00125-020-05245-x - DOI - PubMed
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