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. 2021 Oct;28(10):5456-5460.
doi: 10.1245/s10434-021-10500-5. Epub 2021 Jul 29.

Debate: Postmastectomy Radiation Therapy in T1/2N1 Disease

Anees B Chagpar  1
Affiliations

Debate: Postmastectomy Radiation Therapy in T1/2N1 Disease

Anees B Chagpar. Ann Surg Oncol. 2021 Oct.

Abstract

Although postmastectomy radiation therapy is known to reduce local recurrence in patients with T1/2N1 breast cancer, some have postulated that not all patients require this treatment. In this era of genomic analyses and personalized therapy, clinicians have debated whether the toxicity of post-mastectomy radiation therapy (PMRT) can be avoided for some subsets of patients. However, the data in this regard remain controversial, particularly as surgeons de-escalate the surgical management of the axilla. Several ongoing clinical trials may provide a glimpse into optimal management in this scenario. However, the "right" answer to this debate currently remains unclear.

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References

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