Selection criteria for large core trials: rationale for the ANGEL-ASPECT study design

Zeguang Ren^#¹, Xiaochuan Huo^#², Gaoting Ma², Xu Tong², Jay Kumar³, Elliot Pressman⁴, Wenhuo Chen⁵, Guangxiong Yuan⁶, Alvin Yi-Chou Wang⁷, Ming Wei⁸, Jiangang Zhang⁹, Guangxian Nan¹⁰, Qiyi Zhu¹¹, Yajie Liu¹², Liyong Zhang¹³, Weigen Song¹⁴, Zhiming Zhou¹⁵, Guoqing Wang¹⁶, Tianxiao Li¹⁷, Jun Luo¹⁸, En Wang¹⁹, Wentong Ling²⁰, Dongsheng Ju²¹, Cunfeng Song²², Shu-Dong Liu²³, Liqiang Gui²⁴, Tong Li²⁵, Yan Liu²⁶, Junfeng Zhao²⁷, Zaiyu Guo²⁸, Hongbo Zheng²⁹, Yaxuan Sun³⁰, Na Xu³¹, Yong Jun Wang³², Zhongrong Miao³³; ANGEL-ASPECT Investigators and ANGEL-ASPECT Steering Committee

Collaborators, Affiliations

Collaborators

ANGEL-ASPECT Investigators and ANGEL-ASPECT Steering Committee:
Miao Zhongrong, Ren Zeguang, Vitor Mendes Pereira, Huo Xiaochuan, Ma Gaoting Tong Xu, Zhang Xuelei, Sun Dapeng, Liu Zhenqiang, Yang Ming, Zhang Yupeng, Nie Ximing, Wei Na, Yang Bo, Meng Xia, Pan Yuesong, Wang Anxin, Liu Liping, Wang Yilong, Wang Yongjun, Ji Xunming, Liu Xinfeng, Dong Qiang, Xu Anding, Yang Qingwu, Geng Xiaokun, Zhang Shiyong, Zhou Zhiming, Chen Wenhuo, Wang Yizhou, Liao Geng, Liu Yajie, Ling Wentong, L I Tong Xu Guodong, Gui Liqiang, Li Tianxiao Zhang Jiangang, Ju Dongsheng, Zhao Junfeng, Shi Haibin, Pen Ya, Liu Yan, Shi Hongchao, Wu Jin, Ding Yasuo, Song Weigen, Li Di Jiang Changchun, Zhu Qiyi, Han Hongxing, Wang Guoqing, Song Cunfeng, L I Weirong Zhao Jing, Bi Yong, Zheng Hongbo, Luo Jun, Li Jinglun Wei Ming, Guo Zaiyu, Yin Congguo, Wang En, Liu Shudong, Cai Chuwei, Zhang Meng, Cai Xueli, Nan Guangxian, Zhang Liyong, Yang Hua, Sun Yaxuan, Xu Na, Yang Xinguang, Yuan Guangxiong, Dai Linzhi, Huang Wenguo, Gao Zongen, Shi Qing, Tang Yufeng, Yue Wencan, Wen Changming, Miao Zhongrong, Ren Zeguang, Vitor Mendes Pereira, Wang Yongjun, Wang Yilong, Liu Liping, David Liebeskind

Affiliations

¹ Department of Neurosurgery, Cleveland Clinic Martin Health, Port St Lucie, Florida, USA.
² Department of Interventional Neuroradiology, Beijing Tiantan Hospital, Beijing, China.
³ Department of Neurosurgery, University of South Florida, Tampa, Florida, USA.
⁴ Department of Neurosurgery and Brain Repair, University of South Florida, Tampa, Florida, USA.
⁵ Department of Neurology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, Fujian, China.
⁶ Department of Emergency, Xiangtan Central Hospital, Xiangtan, Hunan, China.
⁷ Department of Neurosurgery, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, Guangdong, China.
⁸ Department of Neurosurgery, Tianjin Huanhu Hospital, Tianjin, China.
⁹ Department of Neurology, Anyang People's Hospital, Anyang, Henan, China.
¹⁰ Department of Neurology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China.
¹¹ Department of Neurology, Linyi People's Hospital, Linyi, Shandong, China.
¹² Department of Neurosurgery, Shenzhen Hospital of Southern Medical University, Shenzhen, Guangdong, China.
¹³ Department of Neurosurgery, Liaocheng People's Hospital, Liaocheng, Shandong, China.
¹⁴ Department of Neurology, Yancheng Third People's Hospital, Yancheng, Jiangsu, China.
¹⁵ Department of Neurology, Yijishan Hospital of Wannan Medical College, Wuhu, Anhui, China.
¹⁶ Department of Neurology, Bin zhou People's Hospital, Binzhou, Shandong, China.
¹⁷ Department of Cerebrovascular Disease, Henan Provincial People's Hospital, Zhengzhou, Henan, China.
¹⁸ Department of Neurology, Sichuan Mianyang 404 Hospital, Mianyang, Sichuan, China.
¹⁹ Department of Neurology, Taizhou Hospital of Zhejiang Province, Linhai, Zhejiang, China.
²⁰ Department of Neurology, ZhongShan City People's Hospital, Zhongshan, China.
²¹ Department of Neurology, Songyuan Jilin oil Field Hospital, Songyuan, Jilin, China.
²² Department of Interventional Neuroradiology, Liaocheng 3rd People's Hospital, Liaocheng, Shandong, China.
²³ Department of Neurology, Yongchuan Hospital of Chongqing Medical University, Chongqing, China.
²⁴ Emergency and Critical Stroke Ambulance Center, Langfang Changzheng Hospital, Langfang, Hebei, China.
²⁵ Department of Neurosurgery, Nanning Second Peoples Hospital, Nanning, Guangxi, China.
²⁶ Department of Neurology, Jingjiang People's Hospital, Jingjiang, Jiangsu, China.
²⁷ Department of Neurology, SiPing Central People's Hospital, Siping, Jilin, China.
²⁸ Department of Neurology, Tianjin teda Hospital, Tianjin, China.
²⁹ Department of Neurology, Sichuan University West China Hospital, Chengdu, Sichuan, China.
³⁰ Department of Neurology, Shanxi Provincial Peoples Hospital, Taiyuan, Shanxi, China.
³¹ Department of Neurology, Xiamen Medical College Affiliated Second Hospital, Xiamen, Fujian, China.
³² Department of Neurology, Beijing Tiantan Hospital, Beijing, China.
³³ Department of Interventional Neuroradiology, Beijing Tiantan Hospital, Beijing, China zhongrongm@163.com.

^# Contributed equally.

PMID: 34326195
PMCID: PMC8785010
DOI: 10.1136/neurintsurg-2021-017798

Selection criteria for large core trials: rationale for the ANGEL-ASPECT study design

Zeguang Ren et al. J Neurointerv Surg. 2022 Feb.

. 2022 Feb;14(2):107-110.

doi: 10.1136/neurintsurg-2021-017798. Epub 2021 Jul 29.

Authors

Collaborators

ANGEL-ASPECT Investigators and ANGEL-ASPECT Steering Committee:
Miao Zhongrong, Ren Zeguang, Vitor Mendes Pereira, Huo Xiaochuan, Ma Gaoting Tong Xu, Zhang Xuelei, Sun Dapeng, Liu Zhenqiang, Yang Ming, Zhang Yupeng, Nie Ximing, Wei Na, Yang Bo, Meng Xia, Pan Yuesong, Wang Anxin, Liu Liping, Wang Yilong, Wang Yongjun, Ji Xunming, Liu Xinfeng, Dong Qiang, Xu Anding, Yang Qingwu, Geng Xiaokun, Zhang Shiyong, Zhou Zhiming, Chen Wenhuo, Wang Yizhou, Liao Geng, Liu Yajie, Ling Wentong, L I Tong Xu Guodong, Gui Liqiang, Li Tianxiao Zhang Jiangang, Ju Dongsheng, Zhao Junfeng, Shi Haibin, Pen Ya, Liu Yan, Shi Hongchao, Wu Jin, Ding Yasuo, Song Weigen, Li Di Jiang Changchun, Zhu Qiyi, Han Hongxing, Wang Guoqing, Song Cunfeng, L I Weirong Zhao Jing, Bi Yong, Zheng Hongbo, Luo Jun, Li Jinglun Wei Ming, Guo Zaiyu, Yin Congguo, Wang En, Liu Shudong, Cai Chuwei, Zhang Meng, Cai Xueli, Nan Guangxian, Zhang Liyong, Yang Hua, Sun Yaxuan, Xu Na, Yang Xinguang, Yuan Guangxiong, Dai Linzhi, Huang Wenguo, Gao Zongen, Shi Qing, Tang Yufeng, Yue Wencan, Wen Changming, Miao Zhongrong, Ren Zeguang, Vitor Mendes Pereira, Wang Yongjun, Wang Yilong, Liu Liping, David Liebeskind

Affiliations

¹ Department of Neurosurgery, Cleveland Clinic Martin Health, Port St Lucie, Florida, USA.
² Department of Interventional Neuroradiology, Beijing Tiantan Hospital, Beijing, China.
³ Department of Neurosurgery, University of South Florida, Tampa, Florida, USA.
⁴ Department of Neurosurgery and Brain Repair, University of South Florida, Tampa, Florida, USA.
⁵ Department of Neurology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, Fujian, China.
⁶ Department of Emergency, Xiangtan Central Hospital, Xiangtan, Hunan, China.
⁷ Department of Neurosurgery, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, Guangdong, China.
⁸ Department of Neurosurgery, Tianjin Huanhu Hospital, Tianjin, China.
⁹ Department of Neurology, Anyang People's Hospital, Anyang, Henan, China.
¹⁰ Department of Neurology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China.
¹¹ Department of Neurology, Linyi People's Hospital, Linyi, Shandong, China.
¹² Department of Neurosurgery, Shenzhen Hospital of Southern Medical University, Shenzhen, Guangdong, China.
¹³ Department of Neurosurgery, Liaocheng People's Hospital, Liaocheng, Shandong, China.
¹⁴ Department of Neurology, Yancheng Third People's Hospital, Yancheng, Jiangsu, China.
¹⁵ Department of Neurology, Yijishan Hospital of Wannan Medical College, Wuhu, Anhui, China.
¹⁶ Department of Neurology, Bin zhou People's Hospital, Binzhou, Shandong, China.
¹⁷ Department of Cerebrovascular Disease, Henan Provincial People's Hospital, Zhengzhou, Henan, China.
¹⁸ Department of Neurology, Sichuan Mianyang 404 Hospital, Mianyang, Sichuan, China.
¹⁹ Department of Neurology, Taizhou Hospital of Zhejiang Province, Linhai, Zhejiang, China.
²⁰ Department of Neurology, ZhongShan City People's Hospital, Zhongshan, China.
²¹ Department of Neurology, Songyuan Jilin oil Field Hospital, Songyuan, Jilin, China.
²² Department of Interventional Neuroradiology, Liaocheng 3rd People's Hospital, Liaocheng, Shandong, China.
²³ Department of Neurology, Yongchuan Hospital of Chongqing Medical University, Chongqing, China.
²⁴ Emergency and Critical Stroke Ambulance Center, Langfang Changzheng Hospital, Langfang, Hebei, China.
²⁵ Department of Neurosurgery, Nanning Second Peoples Hospital, Nanning, Guangxi, China.
²⁶ Department of Neurology, Jingjiang People's Hospital, Jingjiang, Jiangsu, China.
²⁷ Department of Neurology, SiPing Central People's Hospital, Siping, Jilin, China.
²⁸ Department of Neurology, Tianjin teda Hospital, Tianjin, China.
²⁹ Department of Neurology, Sichuan University West China Hospital, Chengdu, Sichuan, China.
³⁰ Department of Neurology, Shanxi Provincial Peoples Hospital, Taiyuan, Shanxi, China.
³¹ Department of Neurology, Xiamen Medical College Affiliated Second Hospital, Xiamen, Fujian, China.
³² Department of Neurology, Beijing Tiantan Hospital, Beijing, China.
³³ Department of Interventional Neuroradiology, Beijing Tiantan Hospital, Beijing, China zhongrongm@163.com.

^# Contributed equally.

PMID: 34326195
PMCID: PMC8785010
DOI: 10.1136/neurintsurg-2021-017798

No abstract available

Keywords: stroke; thrombectomy.

PubMed Disclaimer

Conflict of interest statement

Competing interests: None declared.

References

1. Jadhav AP, Hacke W, Dippel DWJ, et al. . Select wisely: the ethical challenge of defining large core with perfusion in the early time window. J Neurointerv Surg 2021;13:497–9. 10.1136/neurintsurg-2021-017386 - DOI - PubMed
1. Sarraj A, Campbell B, Ribo M, et al. . Selection criteria for large core trials: dogma or data? J Neurointerv Surg 2021;13:500–4. 10.1136/neurintsurg-2021-017498 - DOI - PubMed
1. Campbell BCV, Majoie CBLM, Albers GW, et al. . Penumbral imaging and functional outcome in patients with anterior circulation ischaemic stroke treated with endovascular thrombectomy versus medical therapy: a meta-analysis of individual patient-level data. Lancet Neurol 2019;18:46–55. 10.1016/S1474-4422(18)30314-4 - DOI - PubMed
1. Bouslama M, Barreira CM, Haussen DC, et al. . Endovascular reperfusion outcomes in patients with a stroke and low ASPECTS is highly dependent on baseline infarct volumes. J Neurointerv Surg 2021. 10.1136/neurintsurg-2020-017184. [Epub ahead of print: 15 Mar 2021]. - DOI - PubMed
1. van Horn N, Kniep H, Broocks G, et al. . ASPECTSs interobserver agreement of 100 Investigators from the TENSION study. Clin Neuroradiol 2021. 10.1007/s00062-020-00988-x. [Epub ahead of print: 27 Jan 2021]. - DOI - PMC - PubMed

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Selection criteria for large core trials: rationale for the ANGEL-ASPECT study design

Collaborators

Affiliations

Selection criteria for large core trials: rationale for the ANGEL-ASPECT study design

Authors

Collaborators

Affiliations

Conflict of interest statement

References

MeSH terms

LinkOut - more resources

Full Text Sources

Medical