Neural networks learn the motions of molecular machines

Timothy Grant^{1

2}

Affiliations

¹ John and Jeanne Rowe Center for Research in Virology, Morgridge Institute for Research, Madison, WI, USA. tgrant@morgridge.org.
² Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA. tgrant@morgridge.org.

Comment

Timothy Grant. Nat Methods. 2021 Aug.

. 2021 Aug;18(8):869-871.

doi: 10.1038/s41592-021-01235-y.

Timothy Grant^{1

2}

¹ John and Jeanne Rowe Center for Research in Virology, Morgridge Institute for Research, Madison, WI, USA. tgrant@morgridge.org.
² Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA. tgrant@morgridge.org.

No abstract available

Comment on

CryoDRGN: reconstruction of heterogeneous cryo-EM structures using neural networks.
Zhong ED, Bepler T, Berger B, Davis JH. Zhong ED, et al. Nat Methods. 2021 Feb;18(2):176-185. doi: 10.1038/s41592-020-01049-4. Epub 2021 Feb 4. Nat Methods. 2021. PMID: 33542510 Free PMC article.
Deep learning-based mixed-dimensional Gaussian mixture model for characterizing variability in cryo-EM.
Chen M, Ludtke SJ. Chen M, et al. Nat Methods. 2021 Aug;18(8):930-936. doi: 10.1038/s41592-021-01220-5. Epub 2021 Jul 29. Nat Methods. 2021. PMID: 34326541 Free PMC article.

1. Zhong, E. D., Bepler, T., Berger, B. & Davis, J. H. Nat. Methods 18, 176–185 (2021). - DOI
1. Chen, M. & Ludtke, S. Nat. Methods https://doi.org/10.1038/s41592-021-01220-5 (2021).
1. Yip, K. M., Fischer, N., Paknia, E., Chari, A. & Stark, H. Nature 587, 157–161 (2020). - DOI
1. Nakane, T. et al. Nature 587, 152–156 (2020). - DOI
1. Cheng, Y., Grigorieff, N., Penczek, P. A. & Walz, T. Cell 161, 438–449 (2015). - DOI