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Review
. 2021 Sep:141:111917.
doi: 10.1016/j.biopha.2021.111917. Epub 2021 Jul 16.

CRISPR: History and perspectives to the future

Z Kozovska  1 , S Rajcaniova  2 , P Munteanu  3 , S Dzacovska  4 , L Demkova  5
Affiliations
Free article
Review

CRISPR: History and perspectives to the future

Z Kozovska et al. Biomed Pharmacother. 2021 Sep.
Free article

Abstract

This review summarizes the information about the history and future of the CRISPR/Cas9 method. Genome editing can be perceived as a group of technologies that allow scientists to change the DNA of an organism. These technologies involve the deletion, insertion, or modification of the genome at a specific site in a DNA sequence. Gene therapy in humans has a perspective to be used to eliminate the gene responsible for a particular genetic disorder. The review focuses on the key elements of this promising method and the possibility of its application in the treatment of cancer and genetic diseases.

Keywords: CRISPR; Cas endonucleases; Gene engineering; On or off-targets effects.

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