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Review
. 2021 Nov;93(11):6100-6115.
doi: 10.1002/jmv.27246. Epub 2021 Aug 16.

Regulatory effect of m6 A modification on different viruses

Pei-Lun Yu  1 , San-Jie Cao  1 , Rui Wu  1 , Qin Zhao  1 , Qi-Gui Yan  1
Affiliations
Review

Regulatory effect of m6 A modification on different viruses

Pei-Lun Yu et al. J Med Virol. 2021 Nov.

Abstract

N6 -methyladenosine (m6 A) modification is the most common and reversible posttranscriptional modification of RNA in eukaryotes, which is mainly regulated by methyltransferase, demethylase, and specific binding protein. The replication of the virus and host immune response to the virus are affected by m6 A modification. In different kinds of viruses, m6 A modification has two completely opposite regulatory functions. This paper reviews the regulatory effects of m6 A modification on different viruses and provides a reference for studying the regulatory effects of RNA epitranscriptomic modification.

Keywords: N6-methyladenosine (m6A); regulatory effect; virus.

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References

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