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. 2022 Jan;21(1):e1-e4.
doi: 10.1016/j.jcf.2021.07.005. Epub 2021 Jul 27.

Urinary tract infections in cystic fibrosis patients

Seth A Reasoner  1 , Kyle T Enriquez  2 , Benjamin Abelson  3 , Steven Scaglione  2 , Bennett Schneier  1 , Michael G O'Connor  4 , Gerald Van Horn  5 , Maria Hadjifrangiskou  6
Affiliations

Urinary tract infections in cystic fibrosis patients

Seth A Reasoner et al. J Cyst Fibros. 2022 Jan.

Abstract

Improved understanding of non-respiratory infections in cystic fibrosis (CF) patients will be vital to sustaining the increased life span of these patients. To date, there has not been a published report of urinary tract infections (UTIs) in CF patients. We performed a retrospective chart review at a major academic medical center during 2010-2020 to determine the features of UTIs in 826 CF patients. We identified 108 UTI episodes during this period. Diabetes, distal intestinal obstruction syndrome (DIOS), and nephrolithiasis were correlated with increased risk of UTIs. UTIs in CF patients were less likely to be caused by Gram-negative rods compared to non-CF patients and more likely to be caused by Enterococcus faecalis. The unique features of UTIs in CF patients highlight the importance of investigating non-respiratory infections to ensure appropriate treatment.

Keywords: Antibiotic resistance; Cystic fibrosis; Cystitis; Urinary tract infection.

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Conflict of interest statement

Declaration of Competing Interest All authors declare that they have no conflicts of interest.

Figures

Figure 1.
Figure 1.
Causal Organisms of UTIs in CF patients 1a. Distribution of casual organisms of UTI’s in CF patients. 1b. Comparison of casual organisms in CF patients and the general patient population at our medical center as previously published. P values were calculated with Fisher’s exact test.
See this image and copyright information in PMC

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