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. 2022 Jan;22(1):322-323.
doi: 10.1111/ajt.16775. Epub 2021 Aug 31.

Efficiency of a boost with a third dose of anti-SARS-CoV-2 messenger RNA-based vaccines in solid organ transplant recipients

Arnaud Del Bello  1   2   3 , Florence Abravanel  2   3   4 , Olivier Marion  1   2   3 , Chloé Couat  1 , Laure Esposito  1 , Laurence Lavayssière  1 , Jacques Izopet  2   3   4 , Nassim Kamar  1   2   3
Affiliations

Efficiency of a boost with a third dose of anti-SARS-CoV-2 messenger RNA-based vaccines in solid organ transplant recipients

Arnaud Del Bello et al. Am J Transplant. 2022 Jan.
No abstract available

Keywords: clinical research/practice; immunosuppression/immune modulation; infection and infectious agents - viral; infectious disease; vaccine.

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Figures

FIGURE 1
FIGURE 1
(A) Anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies before and after vaccination in patients tested with different assays. Results are expressed as means ± SEM. ****p < .0001. (B) Anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies before and after vaccination in patients tested with the Wantai enzyme-linked immunosorbent assay test. Results are expressed as means ± SEM. ****p < .0001. (C) Anti-SARS-CoV-2 antibodies titers before and after vaccination in patients who were tested with the Wantai test and who had no detectable antibodies titers before the third dose. A positive test using the Wantai assay was defined by a signal-to-cut-off ratio (S/CO) >1.1. ****p < .0001. (D) Anti-SARS-CoV-2 antibody titers before and after vaccination in patients who were tested with the Wantai test and who had detectable antibodies titers before the third dose. Results are expressed as means ± SD. A positive test using the Wantai assay was defined by a S/CO >1.1. ***p = .004. **p = .017 [Color figure can be viewed at wileyonlinelibrary.com]
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References

    1. Marinaki S, Adamopoulos S, Degiannis D, et al. Immunogenicity of SARS-CoV-2 BNT162b2 vaccine in solid organ transplant recipients. Am J Transplant. 2021;21(8):2913–2915. https://orcid.org/0000-0002-5920-3086. - PMC - PubMed
    1. Marion O, Del "Bello A, Abravanel F, et al. Safety and immunogenicity of anti-SARS-CoV-2 messenger RNA vaccines in recipients of solid organ transplants. Ann Intern Med. 2021; [published online ahead of print May 25, 2021]. https://doi.org/10.7326/M21-1341 - DOI - PMC - PubMed
    1. Kamar N, Abravanel F, Marion O, Couat C, Izopet J, Del Bello A. Three doses of an mRNA Covid-19 vaccine in solid-organ transplant recipients. N Engl J Med. 2021;385:661–662. http://www.ncbi.nlm.nih.gov/pubmed/34161700. - PMC - PubMed
    1. Werbel WA, Boyarsky BJ, Ou MT, et al. Safety and immunogenicity of a third dose of SARS-CoV-2 vaccine in solid organ transplant recipients: a case series. Ann Intern Med. 2021; [published online ahead of print June 15, 2021]. https://doi.org/10.7326/L21-0282 - DOI - PMC - PubMed
    1. Abravanel F, Miédouge M, Chapuy-Regaud S, Mansuy JM, Izopet J. Clinical performance of a rapid test compared to a microplate test to detect total anti SARS-CoV-2 antibodies directed to the spike protein. J Clin Virol. 2020;130:104528. https://pubmed.ncbi.nlm.nih.gov/32771904/ - PMC - PubMed