Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Nov;79(11):2358-2369.
doi: 10.1016/j.joms.2021.06.023. Epub 2021 Jun 22.

Novel Prediction Models for Patients With Oral Squamous Cell Carcinoma at Different Anatomical Sites

Keyuan Liu  1 , Chen Lin  1 , Linkun Zhang  2
Affiliations

Novel Prediction Models for Patients With Oral Squamous Cell Carcinoma at Different Anatomical Sites

Keyuan Liu et al. J Oral Maxillofac Surg. 2021 Nov.

Abstract

Purpose: The individualized prediction of oral cavity squamous cell carcinoma (OC-SCC) is essential and should be as comprehensive as possible. The aim of this study was to identify new risk factors and develop nomograms comparing all anatomic sites of the oral cavity.

Materials and methods: We performed a retrospective cohort study using the Surveillance, Epidemiology, and End Results (SEER) database. All patients with OC-SCC diagnosed from 2004 to 2015 were selected and divided into the training cohort and the validation cohort. Age, gender, race, marital status, primary site, tumor grade, American Joint Committee on Cancer (AJCC) stage, TNM stage, surgical treatment, radiotherapy and chemotherapy were identified as predictor variables. The overall survival (OS) and disease specific survival (DSS) were identified as outcome variables. Kaplan-Meier method with log-rank test, univariate and multivariate cox regression analysis were performed. Independent prognostic factors were used to develop 3- and 5-year nomograms. Hazard ratio (HR) and corresponding 95% confidence interval (CI) showed the influence of each factor on OS or DSS. Concordance indexes (C-indexes) and calibration curves verified the nomograms internally and externally.

Results: A total of 12,346 patients were included. Marital status and chemotherapy were independent prognostic factors (P < .05). Tumors occurring on the cheek mucosa had the highest risk in OS (HR, 2.0, 95% CI, 1.7-2.3) and DSS (HR, 4.7, 95% CI, 3.6-6.0), while tumors occurring on the lip had the lowest risk in OS (HR, 1.0) and DSS (HR,1.0). The C-indexes for OS in the training and validation sets were 0.767 and 0.770, respectively, and for DSS were 0.800 and 0.799, respectively.

Conclusion: Marital status and chemotherapy independently affect OC-SCC patients' survival. The prognosis is least favorable for tumors occurring on the cheek mucosa and most favorable for tumors occurring on the lip.

PubMed Disclaimer