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Review
. 2021 Jul 31;9(1):62.
doi: 10.1186/s40364-021-00316-6.

Novel strategies for immuno-oncology breakthroughs with cell therapy

Hongtao Liu  1   2 , Chongxian Pan  3   4 , Wenru Song  3   5 , Delong Liu  3   6 , Zihai Li  3   7 , Lei Zheng  8   9
Affiliations
Review

Novel strategies for immuno-oncology breakthroughs with cell therapy

Hongtao Liu et al. Biomark Res. .

Abstract

Cell therapy has evolved rapidly in the past several years with more than 250 clinical trials ongoing around the world. While more indications of cellular therapy with chimeric antigen receptor - engineered T cells (CAR-T) are approved for hematologic malignancies, new concepts and strategies of cellular therapy for solid tumors are emerging and are discussed. These developments include better selections of targets by shifting from tumor-associated antigens to personalized tumor-specific neoantigens, an enhancement of T cell trafficking by breaking the stromal barriers, and a rejuvenation of exhausted T cells by targeting immunosuppressive mechanisms in the tumor microenvironment (TME). Despite significant remaining challenges, we believe that cell therapy will once again lead and revolutionize cancer immunotherapy before long because of the maturation of technologies in T cell engineering, target selection and T cell delivery. This review highlighted the recent progresses reported at the 2020 China Immuno-Oncology Workshop co-organized by the Chinese American Hematologist and Oncologist Network (CAHON), the China National Medical Product Administration (NMPA), and Tsinghua University.

Keywords: CAR-T; Cellular Therapy; Neoantigen; TCR-T; TME.

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Conflict of interest statement

Wenru Song is an employee of Kira Pharmaceuticals. The authors declare that they have no competing interests for this manuscript, but have different competing interests outside this manuscript.

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