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Comparative Study
. 2021 Oct;37(10):865-867.
doi: 10.1016/j.tig.2021.06.001. Epub 2021 Jul 28.

Cats - telomere to telomere and nose to tail

Leslie A Lyons  1
Affiliations
Comparative Study

Cats - telomere to telomere and nose to tail

Leslie A Lyons. Trends Genet. 2021 Oct.

Abstract

Feline genomic medicine can decode human variants of uncertain significance (VUSs). Telomere-to-telomere genome assemblies are feasible for all felid species, supporting genetic evolution and speciation studies. Their highly conserved genomic organization compared to humans suggests cats may also decipher the intergenic variation affecting the 3D chromosome structures influencing gene regulation.

Keywords: felines; gapless assembly; genome editing; genome sequencing; phase-genome; precision medicine.

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