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Comment
. 2021 Oct;44(10):769-770.
doi: 10.1016/j.tins.2021.07.005. Epub 2021 Jul 28.

T cells direct microglial repair of white matter after stroke

Kristy A Zera  1 , Marion S Buckwalter  2
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Comment

T cells direct microglial repair of white matter after stroke

Kristy A Zera et al. Trends Neurosci. 2021 Oct.

Abstract

A recent paper by Shi et al. defines the role of regulatory T cells (Tregs) in white matter recovery after ischemic stroke. This study elucidates the mechanisms by which Tregs direct microglia to alter their phenotype to support oligodendrogenesis, thereby improving white matter integrity and functional recovery after stroke in mice.

Keywords: T lymphocytes; ischemic stroke; oligodendrocytes; white matter repair.

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Conflict of interest statement

Declaration of interests The authors declare no conflicts of interest.

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