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. 2021 Nov;45(11):3359-3369.
doi: 10.1007/s00268-021-06264-4. Epub 2021 Jul 31.

Preoperative Neutrophil-to-Lymphocyte Ratio may Predict Postoperative Pneumonia in Stage I-III Gastric Cancer Patients After Curative Gastrectomy: A Retrospective Study

Mikito Mori  1   2 , Kiyohiko Shuto  3 , Atsushi Hirano  4 , Kazuo Narushima  4 , Chihiro Kosugi  3 , Masato Yamazaki  3 , Keiji Koda  3 , Masahiro Yoshida  4
Affiliations

Preoperative Neutrophil-to-Lymphocyte Ratio may Predict Postoperative Pneumonia in Stage I-III Gastric Cancer Patients After Curative Gastrectomy: A Retrospective Study

Mikito Mori et al. World J Surg. 2021 Nov.

Abstract

Background: Several studies have demonstrated that diverse systemic inflammatory-based prognostic parameters predict a poor prognosis in patients with gastric cancer. However, few studies have focused on the relationships between postoperative complications and systemic inflammatory-based prognostic parameters after curative gastrectomy. We investigated the relationships between postoperative complications and these parameters and assessed the clinical utility of the parameters as predictors of postoperative complications in patients with stage I-III gastric cancer.

Methods: We retrospectively reviewed 300 patients who underwent curative gastrectomy for stage I-III gastric cancer. All postoperative complications were classified as infectious or noninfectious. We evaluated the relationships between postoperative complications and clinical factors, including systemic inflammatory-based prognostic parameters.

Results: In total, 101 patients (33.7%) had postoperative Clavien-Dindo grade II-IV complications, and 54 (18.0%) patients developed infectious complications including pancreatic fistula, pneumonia, anastomotic leak, intra-abdominal abscess, and cholecystitis. The relationships between postoperative complications and systemic inflammatory-based prognostic parameters were evaluated by the areas under the receiver operating characteristic curves. Postoperative pneumonia was identified as the most sensitive complication to the systemic inflammatory-based prognostic parameters. Multivariate analysis revealed that preoperative neutrophil-to-lymphocyte ratio (odds ratio, 14.621; 95% confidence interval, 1.160-184.348; p = 0.038) was an independent predictor of pneumonia.

Conclusions: Preoperative neutrophil-to-lymphocyte ratio may be a useful predictor of postoperative pneumonia in patients with stage I-III gastric cancer after curative gastrectomy.

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References

    1. Bray F, Ferlay J, Soerjomataram I et al (2018) Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 68:394–424 - DOI
    1. Brenkman HJ, Haverkamp L, Ruurda JP et al (2016) Worldwide practice in gastric cancer surgery. World J Gastroenterol 22:4041–4048 - DOI
    1. Jiang N, Deng JY, Ding XW et al (2014) Effect of complication grade on survival following curative gastrectomy for carcinoma. World J Gastroenterol 20:8244–8252 - DOI
    1. Tokunaga M, Tanizawa Y, Bando E et al (2013) Poor survival rate in patients with postoperative intra-abdominal infectious complications following curative gastrectomy for gastric cancer. Ann Surg Oncol 20:1575–1583 - DOI
    1. Hayashi T, Yoshikawa T, Aoyama T et al (2015) Impact of infectious complications on gastric cancer recurrence. Gastric Cancer 18:368–374 - DOI