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Case Reports
. 2022 Mar 1;43(1):69-72.
doi: 10.1097/PAF.0000000000000698.

Histopathological Findings in a Fatal Case of Paraquat Poisoning

Affiliations
Case Reports

Histopathological Findings in a Fatal Case of Paraquat Poisoning

Jacob Joseph Moar et al. Am J Forensic Med Pathol. .

Abstract

Fatal paraquat ingestion presents many interesting pathological findings for the forensic pathologist. The majority of prior research regarding paraquat poisoning has focused on the lung and liver, this article is further directed to and presents some of the histopathological findings present in the brain. Typical macroscopic and histopathological findings of paraquat poisoning were identified in the liver and lungs. The brain was found to be edematous with widening of the centrum semiovale, whereas histologically, it was found that there was extravasation of erythrocytes into the surrounding Virchow-Robin spaces, a finding normally associated with blunt force head injury and, therefore, commonly interpreted by forensic pathologists as a cortical contusion hemorrhage.

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Conflict of interest statement

The authors report no conflict of interest.

References

    1. Clark D, McElligott T, Hurst EW. The toxicity of paraquat. Occup Environ Med . 1966;23(2):126–132.
    1. Grant H, Lantos PL, Parkinson C. Cerebral damage in paraquat poisoning. Histopathology . 1980;4(2):185–195.
    1. Nayak VC, Bakkannavar SM, Sharma S, et al. Paraquat poisoning—a case report. Indian J Forensic Community Med . 2015;2(1):67–70.
    1. Dinis-Oliveira RJ, Duarte JA, Sánchez-Navarro A, et al. Paraquat poisonings: mechanisms of lung toxicity, clinical features, and treatment. Crit Rev Toxicol . 2008;38(1):13–71.
    1. Adachi J, Ishii K, Tomita M, et al. Consecutive administration of paraquat to rats induces enhanced cholesterol peroxidation and lung injury. Arch Toxicol . 2003;77(6):353–357.

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