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. 2022 May 1;33(3):830-834.
doi: 10.1097/SCS.0000000000008054. Epub 2021 Jul 30.

Oral Mucosal Melanoma

Marco Nisi  1 , Rossana Izzetti, Stefano Gennai, Angela Pucci, Chiara Lenzi, Filippo Graziani
Affiliations

Oral Mucosal Melanoma

Marco Nisi et al. J Craniofac Surg. .

Abstract

Purpose: Primary oral mucosal melanoma (OMM) is a rare neoplasm accounting for the 0.2% to 0.8% of all melanomas. The aim of the present manuscript is (1) to describe 2 cases of primary OMM treated at our department, and (2) to perform a systematic literature review on primary OMM occurrence and treatment.

Methods: Two cases of primary OMM were described. A systematic review is presented in order to assess the treatment options, recurrence, metastasis development, and survival rate of primary OMM.

Results: Two patients were referred for the development of a lesion of the hard palate and the maxillary gingival mucosa, respectively. An incisional biopsy was performed in both patients, followed by extensive surgical resection after a thorough consideration of patient history and systemic involvement. The literature search retrieved 447 primary OMM cases. In the 30% of cases, distant metastases were already present at the time of diagnosis. The management of primary OMM most frequently involved surgical treatment and adjuvant radiotherapy.

Conclusions: Primary OMM still represents a challenge for the clinician, as the diagnosis is often performed when metastases have already developed. The prognosis is generally poor, thus highlighting the need for further investigations to improve early diagnosis.

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Conflict of interest statement

The authors report no conflicts of interest.

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