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. 2023 Jan;41(1):33-35.
doi: 10.1016/j.eimc.2021.06.021. Epub 2021 Jul 27.

Effectiveness of the BNT162b2 mRNA Covid-19 vaccine in Spanish healthcare workers

Concepción Núñez López  1 , Juan Manuel González de Abreu  1 , Verónica Pérez-Blanco  2 , Rosa de Miguel Buckley  3 , María Pilar Romero Gómez  4 , Marta Díaz-Menéndez  3 ; La Paz Health Care Workers Vaccination Study Group; Appendix. La Paz Health Care Workers Vaccination Study Group
Affiliations

Effectiveness of the BNT162b2 mRNA Covid-19 vaccine in Spanish healthcare workers

Concepción Núñez López et al. Enferm Infecc Microbiol Clin. 2023 Jan.

Abstract
in English, Spanish

Introduction: Frontline health care workers (HCW) have higher risk than the general population to become infected by SARS.CoV.2, so they were a priority group for Covid-19 vaccine administration. We compared the incidence and prevalence of HCW infected pre-and post-vaccination with the BNT162b2 mRNA COVID-19 vaccine.

Material and methods: Prospective observational study carried out between 01/12/20 and 07/03/21 in La Paz University Hospital, Madrid (Spain). SARS.CoV.2 positive cases in HCW after vaccination were collected and compared to those hospitalized COVID-19 patients at the same hospital.

Results: Two weeks after finishing the first round of vaccinations daily new cases of HCW infections (symptomatic and asymptomatic) decreased substantially and cumulative cases of infected HCW and hospitalized COVID-19 patients started to diverge. No new positive cases of HCW infection were registered seven days after the second dose of BNT162b2 mRNA COVID-19 vaccine.

Conclusions: BNT162b2 mRNA COVID-19 vaccine is highly effective in Spanish HCW.

Introducción: Los trabajadores sanitarios (TS) de primera línea tienen mayor riesgo de infectarse de SARS-CoV-2 que la población general, por lo que han sido un grupo prioritario para la vacunación frente a COVID-19. Comparamos la incidencia y prevalencia de TS infectados antes y después de la vacunación con BNT162b2 mRNA frente a COVID-19.

Material y métodos: Estudio prospectivo observacional realizado entre 01 de diciembre de 2021 en el Hospital Universitario La Paz, Madrid, España. Se registraron los casos positivos para SARS-CoV-2 en TS y se compararon con los hospitalizados por COVID-19.

Resultados: Dos semanas tras la primera ronda de vacunación las nuevas infecciones en TS (sintomáticas y asintomáticos) disminuyeron sustancialmente y los casos acumulados de TS infectados y pacientes hospitalizados por COVID-19 empezaron a divergir. No hubo nuevas infecciones en TS vacunados a los siete días de la segunda dosis de la vacuna.

Conclusión: La vacuna BNT162b2 mRNA frente a SARS-CoV-2 es altamente eficaz en TS españoles.

Keywords: COVID; Healthcare workers; SARS-COV2; Vaccine.

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Figures

Fig. 1
Fig. 1
Daily new cases of COVID19 hospitalized patients, and daily new cases of infected HCW COVID19 pre-and post-vaccination. Footnote: HCW: healthcare workers.
Fig. 2
Fig. 2
Daily new cases of COVID19 in HCW and 14 days cumulative cases per 100,000 habitants in the Madrid region. Footnote: HCW: Healthcare workers.
See this image and copyright information in PMC

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