Differences of Angiogenesis Factors in Tumor and Diabetes Mellitus

Abstract

Angiogenesis, as a process occurring under the regulation of a variety of factors, is one of the important ways of vascular development. It coexists in a variety of pathological and physiological processes. Now a large number of studies have proved that tumor growth, metastasis, and various vascular complications of diabetes are closely related to angiogenesis, and an increasing number of studies have shown that there are many common factors between the two. But angiogenesis is the opposite of the two: it is enhanced in tumors and suppressed in diabetes. Therefore, this review discusses the causes of the phenomenon from the expression of various factors affecting angiogenesis in these two diseases and their effects on angiogenesis in the relevant microenvironment, as well as the application status of these factors or cells as therapeutic targets in the treatment of these two diseases.

Keywords: angiogenesis; diabetes mellitus; differences; hypoxia; tumor; tumor microenvironment.

Figure 1

Interactions between angiogenic factors in diabetes mellitus and cancer. Hypoxia and hyperglycemia are the main characteristics of the microenvironment of tumor and diabetes mellitus. Hypoxia mainly promotes angiogenic factors, while hyperglycemia mainly inhibits them. VEGF, HIF-1, SDF-1, Ang-2, FGF and so on are the main factors affecting angiogenesis. EPCs, Pericytes, TAMS, CAFs, etc. These are the main cells involved in angiogenesis. These factors and cells are closely related to each other. It is the presence of these connections and pathways that account for the huge differences in angiogenesis between diabetes mellitus and tumors.