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Review
. 2021 Jul 10:2021:4977209.
doi: 10.1155/2021/4977209. eCollection 2021.

Cardiovascular Effects Mediated by HMMR and CD44

Kinga Jaskuła  1 , Mariusz Sacharczuk  1   2 , Zbigniew Gaciong  3 , Dominik S Skiba  1
Affiliations
Review

Cardiovascular Effects Mediated by HMMR and CD44

Kinga Jaskuła et al. Mediators Inflamm. .

Abstract

Cardiovascular disease (CVD) is the leading cause of death worldwide. The most dangerous life-threatening symptoms of CVD are myocardial infarction and stroke. The causes of CVD are not entirely clear, and new therapeutic targets are still being sought. One of the factors involved in CVD development among vascular damage and oxidative stress is chronic inflammation. It is known that hyaluronic acid plays an important role in inflammation and is regulated by numerous stimuli, including proinflammatory cytokines. The main receptors for hyaluronic acid are CD44 and RHAMM. These receptors are membrane proteins that differ in structure, but it seems that they can perform similar or synergistic functions in many diseases. Both RHAMM and CD44 are involved in cell migration and wound healing. However, their close association with CVD is not fully understood. In this review, we describe the role of both receptors in CVD.

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Conflict of interest statement

The authors declare that there are no conflicts of interest.

Figures

Figure 1
Figure 1
Protein (a) and mRNA (b) expression of CD44. Prepared on the basis of data from the Human Protein Atlas [37]. Protein expression reported with the units: not detected, low, medium, and high. mRNA expression reported as normalized expression (NX) combined from three transcriptomics datasets (HPA, GTEx, and FANTOM5). Created with BioRender.com.
Figure 2
Figure 2
Diagram describing the role of RHAMM and CD44 receptors in the cardiovascular system. Created with BioRender.com.
See this image and copyright information in PMC

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