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Review
. 2021 Jul 11:2021:9932218.
doi: 10.1155/2021/9932218. eCollection 2021.

Effects and Mechanisms of Resveratrol on Aging and Age-Related Diseases

Dan-Dan Zhou  1 , Min Luo  1 , Si-Yu Huang  1 , Adila Saimaiti  1 , Ao Shang  1 , Ren-You Gan  2   3 , Hua-Bin Li  1
Affiliations
Review

Effects and Mechanisms of Resveratrol on Aging and Age-Related Diseases

Dan-Dan Zhou et al. Oxid Med Cell Longev. .

Abstract

The aging of population has become an issue of great concern because of its rapid increase. Aging is an important risk factor of many chronic diseases. Resveratrol could be found in many foods, such as grapes, red wine, peanuts, and blueberries. Many studies reported that resveratrol possessed various bioactivities, such as antioxidant, anti-inflammatory, cardiovascular protection, anticancer, antidiabetes mellitus, antiobesity, neuroprotection, and antiaging effects. The antiaging mechanisms of resveratrol were mainly ameliorating oxidative stress, relieving inflammatory reaction, improving mitochondrial function, and regulating apoptosis. Resveratrol could be an effective and safe compound for the prevention and treatment of aging and age-related diseases. In this review, we summarize the effects of resveratrol on aging, life extension, and several age-related diseases, with special attention paid to the mechanisms of antiaging action.

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Conflict of interest statement

The authors declare that there is no conflict of interest regarding the publication of this article.

Figures

Figure 1
Figure 1
The effects of resveratrol on age-related diseases. Resveratrol could protect against age-related diseases, such as neurodegenerative diseases, cardiovascular diseases, sarcopenia, infertility, osteoporosis, and cancers.
Figure 2
Figure 2
The mechanisms of resveratrol against aging. Resveratrol could stimulate the activity of nuclear factor erythroid-2 related factor 2 (Nrf2) and promote the activities of antioxidant enzymes, like superoxide dismutase (SOD) and catalase (CAT) to inhibit the production of reactive oxygen species (ROS), thus suppressing oxidative stress. Resveratrol could activate antiaging factor sirtuin1 (Sirt1) and downregulate the Akt/mTOR pathway to inhibit ROS in mitochondria and increase mitochondrial biogenesis and function, which could improve mitochondrial function. Resveratrol could promote the activities of nuclear-factor kappa B (NF-κB) and Sirt1 to decrease the levels of inflammatory markers, like interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), and monocyte chemoattractant protein-1 (MCP-1) to inhibit inflammation. Resveratrol could upregulate Sirt1, subsequently promote forkhead box protein O1 (Foxo1), and inhibit p53, thereby modulating the levels of apoptotic proteins Bim and Bax and antiapoptotic protein Bcl, which could regulate apoptosis.
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References

    1. Bloom D. E., Chatterji S., Kowal P., et al. Macroeconomic implications of population ageing and selected policy responses. The Lancet. 2015;385(9968):649–657. doi: 10.1016/S0140-6736(14)61464-1. - DOI - PMC - PubMed
    1. Fernandez A. F., Fraga M. F. The effects of the dietary polyphenol resveratrol on human healthy aging and lifespan. Epigenetics. 2011;6(7):870–874. doi: 10.4161/epi.6.7.16499. - DOI - PubMed
    1. Pyo I. S., Yun S., Yoon Y. E., Choi J.-W., Lee S.-J. Mechanisms of aging and the preventive effects of resveratrol on age-related diseases. Molecules. 2020;25(20):p. 4649. doi: 10.3390/molecules25204649. - DOI - PMC - PubMed
    1. Lagouge M., Argmann C., Gerhart-Hines Z., et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1α. Cell. 2006;127(6):1109–1122. doi: 10.1016/j.cell.2006.11.013. - DOI - PubMed
    1. Jaul E., Barron J. Age-related diseases and clinical and public health implications for the 85 years old and over population. Frontiers in Public Health. 2017;5:p. 7. - PMC - PubMed