Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2021 Jul 22:2021:5570092.
doi: 10.1155/2021/5570092. eCollection 2021.

Adenoid (Acantholytic) Squamous Cell Carcinoma of Mandibular Gingiva

T Raut  1 , S Keshwar  1 , M R Jaisani  2 , A Shrestha  1
Affiliations
Case Reports

Adenoid (Acantholytic) Squamous Cell Carcinoma of Mandibular Gingiva

T Raut et al. Case Rep Dent. .

Abstract

Introduction: Adenoid (acantholytic) squamous cell carcinoma (ASCC) is a histological variant of squamous cell carcinoma which occurs mainly in the sun-exposed areas of the head and neck region. It is commonly seen among males which mainly occurs in the sixth and seventh decade of life with lip being predominately affected. Limited scientific literature is documenting the intraoral presentation of ASCC in contrast to its usual extraoral lesions associated with the skin. Characteristic pseudo glandular alveolar space formation seen in ASCC often mimics carcinoma of salivary gland origin. In-depth knowledge of histopathological features of ASCC is important to diagnose this uncommon variant. Case Description. An 80-year-old female presented with the chief complaint of the nonhealing lesion in the right lower back region of the jaw for 2 months, associated with pain. A provisional diagnosis of oral cancer was considered, and an incisional biopsy was done. Histopathological presentation of the epithelial tumor island, pseudo glandular duct-like structures, and neoplastic cells showing features of dysplasia and keratin pearl formation confirmed the diagnosis as adenoid (acantholytic) squamous cell carcinoma.

Conclusion: The histopathological presentation of adenoid (acantholytic) squamous cell carcinoma reflects the prognosis and metastatic behavior of the diseases. The knowledge of histopathological features of ASCC would be a guide to the untrained eye for the diagnosis and management of this uncommon variant to minimize the rate of metastasis or reoccurrence.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Figure 1
Figure 1
Erythematous ulcerative growth involving the right alveolar ridge and vestibule.
Figure 2
Figure 2
Section showing epithelial tumor islands with keratin pearls and pseudo glandular duct-like structures (H&E, 10x); inset: pseudo glandular duct-like structures lined by a single layer of cells with the dyskeratotic cell within the space (H&E, 40x).
Figure 3
Figure 3
Epithelial tumor islands within connective tissue showing acantholysis and loss of cellular attachment (H&E, 10x).
Figure 4
Figure 4
Space giving the pseudo glandular presentation (H&E, 10x).
See this image and copyright information in PMC

References

    1. Bray F., Ferlay J., Soerjomataram I., Siegel R. L., Torre L. A., Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians. 2018;68(6):394–424. doi: 10.3322/caac.21492. - DOI - PubMed
    1. Patil S. K., Parimala C. S., Nithin K. P., Ahmed M. B. R., Naik R. Case report adenoid squamous cell carcinoma on buccal mucosa : a case report. Journal of Advanced Medical and Dental Sciences Research. 2014;2(3):142–145.
    1. Pathak J., Swain N., Patel S., Poonja L. S. Histopathological variants of oral squamous cell carcinoma-institutional case reports. Journal of Oral and Maxillofacial Pathology. 2014;18(1):143–145. doi: 10.4103/0973-029X.131945. - DOI - PMC - PubMed
    1. Perez-Ordoñez B., Beauchemin M., Jordan R. C. K. Molecular biology of squamous cell carcinoma of the head and neck. Journal of Clinical Pathology. 2006;59(5):445–453. doi: 10.1136/jcp.2003.007641. - DOI - PMC - PubMed
    1. Chandrakala J., Srinath S., Giraddi G., Kendole R. K. Adenoid squamous cell carcinoma of oral cavity: a case report. Journal of Dentistry. 2018;19(1):68–73. - PMC - PubMed

Publication types

LinkOut - more resources