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. 2021 Jul 14:2021:1738932.
doi: 10.1155/2021/1738932. eCollection 2021.

Epidemiological Trends of Head and Neck Cancer: A Population-Based Study

Kangwen Guo  1 , Weiliang Xiao  2 , Xinggui Chen  3 , Zhenying Zhao  4 , Yuanxiong Lin  1 , Ge Chen  1
Affiliations

Epidemiological Trends of Head and Neck Cancer: A Population-Based Study

Kangwen Guo et al. Biomed Res Int. .

Erratum in

Abstract

Background: Over the past decades, lots of advance have occurred in the prevention, diagnosis, and treatment of head and neck cancer (HNC). However, the contemporaneous incidence and survival trends, on the basis of population-based registry, have not been reported.

Methods: The HNC cancer cases were accessed from the Surveillance, Epidemiology, and End Results (SEER) database. The incidence trend was analyzed by joinpoint analysis, with the survival trend being analyzed by period analysis of relative survival rate (RSR) and Kaplan-Meier analyses. Cox regression analysis was performed to identify the prognostic factors for overall survival.

Results: The general incidence trend of HNC increases slightly, with an average annual percentage change of 0.6%, along with five fluctuating segments. The improvement of net survival over the past decades was showed by increasing 60-month RSR, from 54.1% to 56.0% to 60.9% to 66.8%, which was further confirmed by Kaplan-Meier analyses. Moreover, disparities in incidence and survival patterns can be observed in different subgroups.

Conclusion: A fluctuating incidence pattern and an ever-improving survival were observed in HNC over time.

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Conflict of interest statement

The authors declare no competing financial interests.

Figures

Figure 1
Figure 1
Age-adjusted incidence over the past four decades in head and neck cancer patients in SEER nine registries (a), by race (a), by sex (b), by age at diagnosis (c), and by socioeconomic status (d). SES: socioeconomic status.
Figure 2
Figure 2
Trends in relative survival rates over past decades for head and neck cancer patients in SEER nine registries (a), by races (c, e, and g) and by age groups (b, d, f, and h).
Figure 3
Figure 3
Trends in relative survival rates over past decades for head and neck cancer patients in SEER nine registries by sexes (a, b), by socioeconomic status (c, e, and g), or by stages (d, f, and h).
Figure 4
Figure 4
The 60-month relative survival rates by race (a) and SES (b) and Kaplan-Meier survival analyses according to race (c, e, g, and i) and SES (d, f, h, and j) for head and neck cancer patients in each decade between 1975 and 2014.
See this image and copyright information in PMC

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