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Meta-Analysis
. 2021 Jul 14:2021:9995384.
doi: 10.1155/2021/9995384. eCollection 2021.

RUNX3 Expression Level Is Correlated with the Clinical and Pathological Characteristics in Endometrial Cancer: A Systematic Review and Meta-analysis

Zhen Liu  1 , Zhi-Pan Hong  2 , Shu-Xue Xi  3   4
Affiliations
Meta-Analysis

RUNX3 Expression Level Is Correlated with the Clinical and Pathological Characteristics in Endometrial Cancer: A Systematic Review and Meta-analysis

Zhen Liu et al. Biomed Res Int. .

Retraction in

Abstract

Human Runt-associated transcription factor 3 (RUNX3) plays an important role in the development and progression of endometrial cancer (EC). However, the clinical and pathological significance of RUNX3 in EC needs to be further studied. In order to clarify the clinical and pathological significance of RUNX3, a systematic review and meta-analysis was conducted in EC patients. Keywords RUNX3, endometrial cancer, and uterine cancer were searched in Cochrane Library, Web of Knowledge, PubMed, CBM, MEDLINE, and Chinese CNKI database for data up to Dec 31, 2018. References, abstracts, and meeting proceedings were manually searched in supplementary. Outcomes were various clinical and pathological features. The two reviewers performed the literature searching, data extracting, and method assessing independently. Meta-analysis was performed by RevMan5.3.0. A total of 563 EC patients were enrolled from eight studies. Meta-analysis results showed that the expression of RUNX3 has significant differences in these comparisons: lymph node (LN) metastasis vs. non-LN metastasis (P = 0.26), EC tissues vs. normal tissues (P < 0.00001), clinical stages I/II vs. II/IV (P < 0.00001), muscular infiltration < 1/2 vs. muscular infiltration ≥ 1/2 (P < 0.00001), and G1 vs. G2/G3 (P < 0.00001). The decreasing expression of RUNX3 is associated with poor TNM stage and muscular infiltration. It is indicated that RUNX3 was involved in the suppression effect of EC. However, further multicenter randomized controlled trials are needed considering the small sample size of the included trials.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flow chart for the selection of studies.
Figure 2
Figure 2
Meta-analysis of RUNX3 expression in the endometrial cancer and control group.
Figure 3
Figure 3
Meta-analysis of RUNX3 expression in LN (+) and LN (-) endometrial cancer.
Figure 4
Figure 4
Meta-analysis of low RUNX3 expression in the II–IV stage groups and I–II stage groups.
Figure 5
Figure 5
Meta-analysis of low RUNX3 expression in the muscular infiltration < 1/2 group and ≥1/2 group.
Figure 6
Figure 6
Meta-analysis of low RUNX3 expression in the G1 group and G2–G3 groups.
Figure 7
Figure 7
Funnel plot: (a) low RUNX3 expression in the EC group and control group; (b) low RUNX3 expression in the LN (+) and LN (-) EC group; (c) low RUNX3 expression in the III–IV stage groups and I–II stage groups; (d) low RUNX3 expression in the muscular infiltration of the EC < 1/2 group and ≥1/2 group; (e) low RUNX3 expression in the G1 group and G2–G3 groups in endometrial cancer.
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