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. 2020;7(1):4-13.
Epub 2020 Jan 29.

Oxygen injury in neonates: which is worse? hyperoxia, hypoxia, or alternating hyperoxia/hypoxia

Tarek Mohamed  1 , Amal Abdul-Hafez  1 , Ira H Gewolb  1 , Bruce D Uhal  2
Affiliations

Oxygen injury in neonates: which is worse? hyperoxia, hypoxia, or alternating hyperoxia/hypoxia

Tarek Mohamed et al. J Lung Pulm Respir Res. 2020.

Abstract

Premature birth results in an increased risk of respiratory distress and often requires oxygen therapy. While the supplemental oxygen has been implicated as a cause of bronchopulmonary dysplasia (BPD), in clinical practice this supplementation usually only occurs after the patient's oxygen saturation levels have dropped. The effect of hyperoxia on neonates has been extensively studied. However, there is an unanswered fundamental question: which has the most impact-hyperoxia, hypoxia or fluctuating oxygen levels? In this review, we will summarize the reported effect of hypoxia, hyperoxia or a fluctuation of oxygen levels (hypoxia/hyperoxia cycling) in preterm neonates, with special emphasis on the lungs.

Keywords: Bronchopulmonary dysplasia; lung injury; oxidative stress; renin angiotensin system.

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Conflict of interest statement

Conflicts of interest Authors declare that there is no conflict of interest.

Figures

Figure 1
Figure 1
Schematic diagram illustrating reactive oxygen species (ROS) generation in neonatal pulmonary disease.
Figure 2
Figure 2
The renin angiotensin system components and its involvement in lung injury.
See this image and copyright information in PMC

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