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. 2021 Jul 15;7(7):e07595.
doi: 10.1016/j.heliyon.2021.e07595. eCollection 2021 Jul.

The inappropriate use of proton pump inhibitors and its associated factors among community-dwelling older adults

Mohammad Rababa  1 , Abeer Rababa'h  2
Affiliations

The inappropriate use of proton pump inhibitors and its associated factors among community-dwelling older adults

Mohammad Rababa et al. Heliyon. .

Abstract

Objectives: Little is known about the inappropriate use of proton pump inhibitors (PPIs) and how mild cognitive impairment (MCI) and high comorbid burden relate to the inappropriate prescribing of PPIs. Therefore, the current study aimed to examine these associations among community-dwelling older adults in Jordan.

Method: This cross-sectional study was conducted on 215 community-dwelling older adults from three local healthcare centers located in Irbid, Jordan. Data about PPI use, including the name of medication, dose, frequency, duration, and indication, were collected retrospectively from a review of the participating older adults' medication cards for November and December 2019. The collected data were evaluated based on the Food and Drug Administration (FDA) guidelines. MCI was measured using the Arabic version of the Montreal Cognitive Assessment, and comorbid burden was measured using the Cumulative Illness Rating Scale for Geriatrics.

Results: Forty-seven percent of the participants were found to have taken a PPI, with 68 % having taken one for a longer period than recommended by the FDA. Older adults with MCI or high comorbid burden were found to be more susceptible than other older adults to the long-term use of PPIs. The logistic regression revealed that MCI is a statistically significant predictor of inappropriate PPI use (p < 0.001).

Conclusion: Inappropriate PPI use is common among community-dwelling older adults in Jordan, with a significantly higher prevalence of inappropriate PPI use in people with MCI than in people with normal cognitive abilities. Future intervention studies are highly recommended to encourage optimal prescribing of PPIs for community-dwelling older adults.

Keywords: Cognitive impairment; Comorbid burden; Cross-sectional; Older adults; Proton pump inhibitors.

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Conflict of interest statement

The authors declare no conflict of interest.

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