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Case Reports
. 2020 Nov 30:23:9-12.
doi: 10.1016/j.euros.2020.11.006. eCollection 2021 Jan.

Carcinosarcoma of the Prostate Masquerading as Benign Prostatic Enlargement: Lesson Learned

Nivash Selvaraj  1 , Narasimhan Ragavan  1 , Saloni Naresh Shah  2
Affiliations
Case Reports

Carcinosarcoma of the Prostate Masquerading as Benign Prostatic Enlargement: Lesson Learned

Nivash Selvaraj et al. Eur Urol Open Sci. .

Erratum in

Abstract

Primary carcinosarcoma of the prostate is an extremely rare and aggressive malignancy. We report a patient who presented with obstructive symptoms and without a history of radiation, prior adenocarcinoma, or androgen deprivation therapy. Transurethral resection of the prostate was performed. Histopathology and immunohistochemistry revealed a confirmatory diagnosis of de novo carcinosarcoma of the prostate. The case is described for its rarity and masquerading nature.

Keywords: Carcinoma; Prostate; Sarcoma.

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Figures

Fig. 1
Fig. 1
Hematoxylin and eosin staining showing (A) carcinomatous focus composed of fused irregular glands with cribriform and central necrosis; (B) sarcomatous areas with spindle and pleomorphic cells and atypical mitosis; and (C) carcinoma with an adjacent sarcomatous area with patchy necrosis.
Fig. 2
Fig. 2
Immunohistochemical staining showing pan-cytokeratin positivity in carcinomatous and sarcomatous cells.
Fig. 3
Fig. 3
Immunohistochemical staining showing (A) NKX3.1 positivity in epithelial elements; (B) prostate-specific antigen negativity in carcinomatous areas; and (C) vimentin positivity in sarcomatous areas and negativity in the glandular component.
See this image and copyright information in PMC

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