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Comment
. 2021 Jul-Aug;16(4):301-302.
doi: 10.1177/15569845211032139. Epub 2021 Aug 1.

Patients with Atrial Fibrillation Undergoing Cardiac Surgery: No Left Atrial Appendage Shall Remain Untouched

Richard P Whitlock  1   2   3 , Emilie P Belley-Cote  1   2   3
Affiliations
Comment

Patients with Atrial Fibrillation Undergoing Cardiac Surgery: No Left Atrial Appendage Shall Remain Untouched

Richard P Whitlock et al. Innovations (Phila). 2021 Jul-Aug.

Abstract

The Left Atrial Appendage Occlusion Study III randomized 4,811 patients with atrial fibrillation and a CHA2DS2VASc score ≥2 undergoing cardiac surgery to surgical left atrial appendage occlusion or no occlusion. At a mean follow-up of 3.8 years, stroke or systemic embolism was reduced by 33% in the occlusion group with no evidence of early or late adverse effects. This review discusses the implication of these findings.

Keywords: cardiac surgery; left atrial appendage; randomized controlled trial; stroke.

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  • Left Atrial Appendage Occlusion during Cardiac Surgery to Prevent Stroke.
    Whitlock RP, Belley-Cote EP, Paparella D, Healey JS, Brady K, Sharma M, Reents W, Budera P, Baddour AJ, Fila P, Devereaux PJ, Bogachev-Prokophiev A, Boening A, Teoh KHT, Tagarakis GI, Slaughter MS, Royse AG, McGuinness S, Alings M, Punjabi PP, Mazer CD, Folkeringa RJ, Colli A, Avezum Á, Nakamya J, Balasubramanian K, Vincent J, Voisine P, Lamy A, Yusuf S, Connolly SJ; LAAOS III Investigators. Whitlock RP, et al. N Engl J Med. 2021 Jun 3;384(22):2081-2091. doi: 10.1056/NEJMoa2101897. Epub 2021 May 15. N Engl J Med. 2021. PMID: 33999547 Clinical Trial.

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