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. 2021 Sep 17;65(10):e0114621.
doi: 10.1128/AAC.01146-21. Epub 2021 Aug 2.

Candida auris Invasive Infections during a COVID-19 Case Surge

Blake M Hanson  1   2   3 , An Q Dinh  2   3 , Truc T Tran  2   3 , Sebastian Arenas  4 , Darryl Pronty  4 , Hayley B Gershengorn  4   5   6 , Tanira Ferreira  4   5 , Cesar A Arias  1   2   3 , Bhavarth S Shukla  4   7
Affiliations

Candida auris Invasive Infections during a COVID-19 Case Surge

Blake M Hanson et al. Antimicrob Agents Chemother. .

Abstract

Clinical cases of C. auris noted during a COVID-19 surge led to an epidemiological, clinical, and genomic investigation. Evaluation identified a close genetic relationship but inconclusive epidemiologic link between all cases. Prolonged hospitalization due to critical illness from COVID-19 and use of antimicrobials may have contributed to clinical infections.

Keywords: COVID-19; Candida auris; outbreak investigation; whole-genome sequencing.

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Figures

FIG 1
FIG 1
(A) Phylogenetic tree of Candida auris isolates (green) with 61 globally representative isolates demonstrating the four major C. auris clades. Outbreak isolates cluster with the African clade isolates. (B) Molecular epidemiological link between isolates and SNP distances between all isolates. The axes show a reciprocal list of the 15 outbreak isolates, and each cell represents the intersection between two isolates to show the epidemiological link (color) and the number of SNPs observed between the two isolates. Isolates demonstrating a common ancestor and putative transmission have either an epidemiologic link and/or a small number of SNPs. All isolates differ by ≤5 SNPs relative to the internal reference isolate NC_1, suggesting all isolates share a single common ancestor, and spread was due to either interpatient transmission or a point-source outbreak.
See this image and copyright information in PMC

References

    1. Falcone M, Tiseo G, Giordano C, Leonildi A, Menichini M, Vecchione A, Pistello M, Guarracino F, Ghiadoni L, Forfori F, Barnini S, Menichetti F, O Degl’Innocenti SA, Barbieri G, Biancalana M, Borselli M, Nencini E, Spinelli S, Antognoli R, Calsolario V, Monzani F, Paterni S, Baldassarri R, Bertini P, Brizzi G, Rocca AD, Malacarne P, Monfroni M, Piagnani C, Carpenè N, Carrozzi L, Celi A, Desideri M, Gherardi M, Serradori M, Cinotti F, Cipriano A, Park N, Forotti G, Mengozzi A, Masi S, Ruberti F, Sciuto M, Virdis A, Maggi F, Galfo V, The Pisa COVID-19 Study Group . 2021. Predictors of hospital-acquired bacterial and fungal superinfections in COVID-19: a prospective observational study. J Antimicrob Chemother 76:1078–1084. 10.1093/jac/dkaa530. - DOI - PMC - PubMed
    1. CDC. 2019. Antibiotic resistance threats in the United States. U.S. Department of Health and Human Services, Atlanta, GA. https://www.cdc.gov/drugresistance/pdf/threats-report/2019-ar-threats-re.... Accessed 20 February 2021.
    1. Jeffery-Smith A, Taori SK, Schelenz S, Jeffery K, Johnson EM, Borman A, Manuel R, Brown CS, Candida auris Incident Management Team . 2018. Candida auris: a review of the literature. Clin Microbiol Rev 31:e00029-17. 10.1128/CMR.00029-17. - DOI - PMC - PubMed
    1. van Duin D, Arias CA, Komarow L, Chen L, Hanson BM, Weston G, Cober E, Garner OB, Jacob JT, Satlin MJ, Fries BC, Garcia-Diaz J, Doi Y, Dhar S, Kaye KS, Earley M, Hujer AM, Hujer KM, Domitrovic TN, Shropshire WC, Dinh A, Manca C, Luterbach CL, Wang M, Paterson DL, Banerjee R, Patel R, Evans S, Hill C, Arias R, Chambers HF, Fowler VG, Kreiswirth BN, Bonomo RA, Multi-Drug Resistant Organism Network Investigators . 2020. Molecular and clinical epidemiology of carbapenem-resistant Enterobacterales in the United StatesA (CRACKLE-2): a prospective cohort study. Lancet Infect Dis 20:731–741. 10.1016/S1473-3099(19)30755-8. - DOI - PMC - PubMed
    1. Shropshire WC, Aitken SL, Pifer R, Kim J, Bhatti MM, Li X, Kalia A, Galloway-Peña J, Sahasrabhojane P, Arias CA, Greenberg DE, Hanson BM, Shelburne SA. 2021. IS26-mediated amplification of blaOXA-1 and blaCTX-M-15 with concurrent outer membrane porin disruption associated with de novo carbapenem resistance in a recurrent bacteraemia cohort. J Antimicrob Chemother 76:385–395. 10.1093/jac/dkaa447. - DOI - PMC - PubMed

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