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. 2021 Oct;15(10):869-877.
doi: 10.1002/term.3232. Epub 2021 Aug 27.

Polyvinylidene fluoride/silk fibroin-based bio-piezoelectric nanofibrous scaffolds for biomedical application

Jeong Chan Lee  1 , Il Won Suh  1 , Chan Hee Park  1   2   3 , Cheol Sang Kim  1   2   3
Affiliations

Polyvinylidene fluoride/silk fibroin-based bio-piezoelectric nanofibrous scaffolds for biomedical application

Jeong Chan Lee et al. J Tissue Eng Regen Med. 2021 Oct.

Abstract

Since the discovery that applying electrical stimulation can promote cell growth, proliferation, and tissue regeneration, research on bio-piezoelectric materials is being actively conducted. In this study, a composite material was prepared by mixing polyvinylidene fluoride (PVDF), a conventional piezoelectric polymer, and silk fibroin (SF), a natural piezoelectric material that recently attracting attention. These two polymers were fabricated into a composite fiber mat using electrospinning technology. To find optimal conditions, SF was added in various ratios to prepare electrospun PVDF/SF mats. The characteristics of these PVDF/SF composite mats were then analyzed through various evaluations and in vitro studies. It was confirmed that PVDF and SF were successfully mixed through scanning electron microscope images and structural analysis such as x-ray diffractometer and Fourier transform infrared. The results revealed that adding an appropriate amount of SF could improve the tensile strength, enhance cell proliferation rate, and generate a voltage similar to that of a conventional PVDF-only electrospinning mat. Such fabricated electrospun PVDF/SF composite mats are expected to be useful in the bio-piezoelectric field because they can maintain piezoelectricity while compensating for the shortcomings, such as low physical properties, of a PVDF electrospun mat.

Keywords: Bombyx mori silk; bio-piezoelectricity; electrospinning.

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References

REFERENCES

    1. Agyemang, F. O., Li, F., Momade, F. W. Y., & Kim, H. (2016). Effect of poly(ethylene oxide) and water on electrospun poly(vinylidene fluoride) nanofibers with enhanced mechanical properties as pre-filter for oil-in-water filtration. Materials Chemistry and Physics, 182, 208-218. https://doi.org/10.1016/j.matchemphys.2016.07.025
    1. Cai, X., Lei, T., Sun, D., & Lin, L. (2017). A critical analysis of the α, β and γ phases in poly(vinylidene fluoride) using FTIR. RSC Advances, 7(25), 15382-15389. https://doi.org/10.1039/c7ra01267e
    1. Cheng, Y., Koh, L. D., Li, D., Ji, B., Han, M. Y., & Zhang, Y. W. (2014). On the strength of beta-sheet crystallites of Bombyx mori silk fibroin. Journal of the Royal Society Interface, 11(96), 20140305. https://doi.org/10.1098/rsif.2014.0305
    1. Gheibi, A., Bagherzadeh, R., Merati, A. A., & Latifi, M. (2014). Electrical power generation from piezoelectric electrospun nanofibers membranes: Electrospinning parameters optimization and effect of membranes thickness on output electrical voltage. Journal of Polymer Research, 21(11). https://doi.org/10.1007/s10965-014-0571-8
    1. Gholipourmalekabadi, M., Samadikuchaksaraei, A., Seifalian, A. M., Urbanska, A. M., Ghanbarian, H., Hardy, J. G., Mozafari, M., Reis, R. L., & Kundu, S. C. (2018). Silk fibroin/amniotic membrane 3D bi-layered artificial skin. Biomedical Materials, 13(3), 035003. https://doi.org/10.1088/1748-605X/aa999b

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