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. 2021 Nov 1:241:118439.
doi: 10.1016/j.neuroimage.2021.118439. Epub 2021 Jul 30.

The psychosis human connectome project: An overview

Caroline Demro  1 , Bryon A Mueller  2 , Jerillyn S Kent  2 , Philip C Burton  3 , Cheryl A Olman  4 , Michael-Paul Schallmo  2 , Kelvin O Lim  5 , Scott R Sponheim  6
Affiliations

The psychosis human connectome project: An overview

Caroline Demro et al. Neuroimage. .

Abstract

Investigations within the Human Connectome Project have expanded to include studies focusing on brain disorders. This paper describes one of the investigations focused on psychotic psychopathology: The psychosis Human Connectome Project (P-HCP). The data collected as part of this project were multimodal and derived from clinical assessments of psychopathology, cognitive assessments, instrument-based motor assessments, blood specimens, and magnetic resonance imaging (MRI) data. The dataset will be made publicly available through the NIMH Data Archive. In this report we provide specific information on how the sample of participants was obtained and characterized and describe the experimental tasks and procedures used to probe neural functions involved in psychotic disorders that may also mark genetic liability for psychotic psychopathology. Our goal in this paper is to outline the data acquisition process so that researchers intending to use these publicly available data can plan their analyses. MRI data described in this paper are limited to data acquired at 3 Tesla. A companion paper describes the study's 7 Tesla image acquisition protocol in detail, which is focused on visual perceptual functions in psychotic psychopathology.

Keywords: Brain; Connectomics; MRI; Neuroimaging; Psychosis; Schizophrenia.

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Figures

Fig. 1.
Fig. 1.
(A). Mean Brief Psychiatric Rating Scale (BPRS) symptom scores for preliminary sample (n = 247; error bars represent standard deviation). (B). Mean Schizotypal Personality Questionnaire (SPQ) symptom scores for preliminary sample (n = 247; error bars represent standard deviation).
Fig. 2.
Fig. 2.
The reward cues (A) and the odd-one-out target stimulus (B) used for the cued reinforcement reaction time task (CRRT; adapted from Simon et al. 2015).
Fig. 3.
Fig. 3.
Cue-probe pairs of the dot pattern expectancy task.
Fig. 4.
Fig. 4.
Social cognition task conditions.
See this image and copyright information in PMC

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