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Comment
. 2021 Jul 1;48(3):e207395.
doi: 10.14503/THIJ-20-7395.

A Review of the Cardiac and Cardiovascular Effects of COVID-19 in Adults and Children

Bibhuti B Das  1 , S Kristen Sexon Tejtel  1 , Shriprasad Deshpande  2 , Lara S Shekerdemian  3
Affiliations
Comment

A Review of the Cardiac and Cardiovascular Effects of COVID-19 in Adults and Children

Bibhuti B Das et al. Tex Heart Inst J. .

Abstract

Symptomatic coronavirus disease 2019 (COVID-19) typically affects the respiratory system but can involve the cardiovascular system. Cardiac complications of COVID-19 can result directly from myocarditis or indirectly from numerous other mechanisms. Differentiating between primary and secondary cardiovascular involvement-our focus in this review-may help to identify the long-term effects of COVID-19 on the heart in adults and children.

Keywords: Angiotensin-converting enzyme 2; COVID-19/complications; SARS-CoV-2; biomarkers; cardiovascular diseases/epidemiology/etiology/physiopathology/virology; comorbidity; coronavirus infections/complications; cytokines/blood; disease progression; myocarditis/etiology.

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Figures

Fig. 1
Fig. 1
Diagram shows several potential mechanisms of cardiovascular involvement in coronavirus disease 2019 (COVID-19). (Created with BioRender.com) ACE2 = angiotensin-converting enzyme 2; ANG = angiotensin; ARDS = acute respiratory disease syndrome; AT1R = angiotensin II type-1 receptor; CRP = C-reactive protein; CXCL = chemokine (CXC motif) ligand; DIC = disseminated intravascular coagulation; Fx = function; IL = interleukin; LDH = lactate dehydrogenase; MI = myocardial infarction; NK = natural killer; RAS = renin-angiotensin system; RV = right ventricular; SIRS = systemic inflammatory response syndrome; TMPRSS2 = transmembrane serine protease 2
See this image and copyright information in PMC

Comment on

  • Myocardial localization of coronavirus in COVID-19 cardiogenic shock.
    Tavazzi G, Pellegrini C, Maurelli M, Belliato M, Sciutti F, Bottazzi A, Sepe PA, Resasco T, Camporotondo R, Bruno R, Baldanti F, Paolucci S, Pelenghi S, Iotti GA, Mojoli F, Arbustini E. Tavazzi G, et al. Eur J Heart Fail. 2020 May;22(5):911-915. doi: 10.1002/ejhf.1828. Epub 2020 Apr 11. Eur J Heart Fail. 2020. PMID: 32275347 Free PMC article.

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