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. 2021 Oct;195(2):286-289.
doi: 10.1111/bjh.17679. Epub 2021 Aug 2.

Vacuoles in neutrophil precursors in VEXAS syndrome: diagnostic performances and threshold

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Vacuoles in neutrophil precursors in VEXAS syndrome: diagnostic performances and threshold

Valentin Lacombe et al. Br J Haematol. 2021 Oct.
No abstract available

Keywords: VEXAS syndrome; autoinflammatory disorder; myelodysplastic syndromes; ubiquitin-activating enzymes; vacuoles.

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References

    1. Beck DB, Ferrada MA, Sikora KA, Ombrello AK, Collins JC, Pei W, et al. Somatic mutations in UBA1 and severe adult-onset autoinflammatory disease. N Engl J Med. 2020;383(27):2628-38.
    1. Lacombe V, Kosmider O, Prévost M, Lavigne C, Urbanski G. Severe joint involvement in VEXAS syndrome: a case report. Ann Intern Med. 2021:L21-0023. https://doi.org/10.7326/L21-0023.
    1. Lazarchick J. Update on anemia and neutropenia in copper deficiency. Curr Opin Hematol. 2012;19:58-60.
    1. Gajendra S, Gupta R, Sharma A, Gupta R, Gogia A. Acute myeloid leukaemia with Pseudo-Chediak-Higashi granules and intracytoplasmic vacuoles. Eur J Haematol. 2011. https://doi.org/10.1111/j.1600-0609.2011.01668.x.
    1. Sayın S, Ünal Ş, Çetin M, Gümrük F. Vacuolization in myeloid and erythroid precursors in a child with menkes disease. Turk J Hematol. 2019;36:203-4.

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