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Randomized Controlled Trial
. 2021 Aug;14(8):e009891.
doi: 10.1161/CIRCINTERVENTIONS.120.009891. Epub 2021 Aug 3.

Placebo-Controlled Efficacy of Percutaneous Coronary Intervention for Focal and Diffuse Patterns of Stable Coronary Artery Disease

Christopher A Rajkumar  1   2 , Matthew Shun-Shin  1   2 , Henry Seligman  1   2 , Yousif Ahmad  1   3 , Takayuki Warisawa  1   4 , Christopher M Cook  5 , James P Howard  1   2 , Sashiananthan Ganesananthan  1 , Laura Amarin  1 , Caitlin Khan  1 , Ayesha Ahmed  6 , Alexandra Nowbar  1   2 , Michael Foley  1   2 , Ravi Assomull  1   2 , Niall G Keenan  7 , Joban Sehmi  7 , Thomas R Keeble  5   8 , John R Davies  5   8 , Kare H Tang  5 , Robert Gerber  9 , Graham Cole  1   2 , Peter O'Kane  10 , Andrew S P Sharp  11   12 , Ramzi Khamis  1   2 , Gajen Kanaganayagam  2 , Ricardo Petraco  1   2 , Neil Ruparelia  1   2 , Iqbal S Malik  2 , Sukhjinder Nijjer  1   2 , Sayan Sen  1   2 , Darrel P Francis  1   2 , Rasha Al-Lamee  1   2
Affiliations
Randomized Controlled Trial

Placebo-Controlled Efficacy of Percutaneous Coronary Intervention for Focal and Diffuse Patterns of Stable Coronary Artery Disease

Christopher A Rajkumar et al. Circ Cardiovasc Interv. 2021 Aug.

Abstract

[Figure: see text].

Trial registration: ClinicalTrials.gov NCT02062593.

Keywords: angina pectoris; coronary artery disease; hemodynamics; ischemia; percutaneous coronary intervention.

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Conflict of interest statement

For Sources of Funding and Disclosures, see page 817.

Figures

Figure 1.
Figure 1.
Impact of placebo-controlled percutaneous coronary intervention (PCI) on dobutamine stress echocardiography (DSE) ischemia. A, Impact of PCI and placebo on DSE ischemia according to physiological pattern of disease, adjusted for baseline instantaneous wave-free ratio (iFR) (A(i)) and baseline fractional flow reserve (FFR) (A(ii)). B, Placebo-controlled impact of PCI on DSE ischemia in diffuse and focal stenoses, adjusted for baseline iFR (B(i)) and baseline FFR (B(ii)).
Figure 2.
Figure 2.
Effect of physiological pattern of disease on the impact of placebo-controlled percutaneous coronary intervention (PCI) on symptom end points. The association between pattern of coronary artery disease as assessed by instantaneous wave-free ratio (iFR)-pullback and the benefit of PCI over placebo for (A) exercise time, (B) Seattle Angina Questionnaire (SAQ) angina frequency, and (C) SAQ derived freedom from angina, after adjustment for baseline iFR values.
Figure 3.
Figure 3.
Impact of quantitative coronary angiography lesion length on placebo-controlled efficacy of percutaneous coronary intervention (PCI) on dobutamine stress echocardiography and symptom end points. The impact of lesion length on (A) stress echo score, (B) exercise time, (C) Seattle Angina Questionnaire (SAQ) angina frequency, and (D) SAQ derived freedom from angina.
See this image and copyright information in PMC

Comment in

References

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